Investig Clin Urol.  2017 Dec;58(Suppl 2):S82-S89. 10.4111/icu.2017.58.S2.S82.

Pathophysiology of the underactive bladder

• Aizawa N
• Igawa Y

• KMID: 2397984
• DOI: http://doi.org/10.4111/icu.2017.58.S2.S82

Abstract

Underactive bladder (UAB), which has been described as a symptom complex suggestive of detrusor underactivity, is usually characterized by prolonged urination time with or without a sensation of incomplete bladder emptying, usually with hesitancy, reduced sensation on filling, and slow stream often with storage symptoms. Several causes such as aging, bladder outlet obstruction, diabetes mellitus, neurologic disorders, and nervous injury to the spinal cord, cauda equine, and peripheral pelvic nerve have been assumed to be responsible for the development of UAB. Several contributing factors have been suggested in the pathophysiology of UAB, including myogenic failure, efferent and/or afferent dysfunctions, and central nervous system dysfunction. In this review article, we have described relationships between individual contributing factors and the pathophysiology of UAB based on previous reports. However, many pathophysiological uncertainties still remain, which require more investigations using appropriate animal models.

Keyword

Aging; Denervation; Diabetic neuropathies; Ischemia; Urinary bladder diseases

MeSH Terms

Aging
Central Nervous System
Denervation
Diabetes Mellitus
Diabetic Neuropathies
Hypesthesia
Ischemia
Models, Animal
Nervous System Diseases
Rivers
Sensation
Spinal Cord
Urinary Bladder Diseases
Urinary Bladder Neck Obstruction
Urinary Bladder*
Urination

Figure

• 

  Fig. 1 Contributing factors and mechanisms involved in underactive bladder.

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