Nat Prod Sci.  2017 Sep;23(3):222-226. 10.20307/nps.2017.23.3.222.

Comparative Effects of Dietary Quercetin and Rutin in Rats Fed with the Lieber-DeCarli Ethanol Diet

• Seo SJ
• Park CH
• Ko IY
• Jeong YH
• Choi YS

• KMID: 2393805
• DOI: http://doi.org/10.20307/nps.2017.23.3.222

Abstract

Flavonoids including quercetin and rutin are a group of naturally occurring compounds widely distributed in plants, especially in buckwheat. Thus, cereal and the leaf of the plant have increasingly used as a source of nutritional and functional foods such as noodle, cake or soup in Korea, Japan and other countries. This study investigated comparative effects of dietary rutin rich in buckwheat and its aglycone, quercetin, on serum biomarkers and antioxidant parameters in rats treated with chronic ethanol. Rats were fed with the liquid diets prepared by the method of Lieber Decarli. Serum alanine transaminase (ALT) and aspartate transaminase (AST) activities increased significantly by alcohol feeding. Dietary flavonoids including rutin, quercetin and their mixtures (1/1, v/v) decreased significantly the activities of serum ALT whereas the feeding of quercetin decreased only the activity of serum AST. The concentration of serum malondialdehydes elevated by chronic alcohol feeding decreased markedly in all the experimental groups that were fed with the flavonoids; however, the combined administration of quercetin or rutin, but not that of rutin or quercetin alone decreased significantly the concentration of liver malondialdehydes to the normal range in rats fed without ethanol. Our results suggested that dietary combined mixture of rutin and quercetin might be effective in ameliorating adverse responses seen in rats exposed to ethanol chronically.

Keyword

Ethanol; Liver; Quercetin; Rutin; Rats

MeSH Terms

Alanine Transaminase
Animals
Aspartate Aminotransferases
Biomarkers
Diet*
Edible Grain
Ethanol*
Fagopyrum
Flavonoids
Functional Food
Japan
Korea
Liver
Methods
Plants
Quercetin*
Rats*
Reference Values
Rutin*
Alanine Transaminase
Aspartate Aminotransferases
Biomarkers
Ethanol
Flavonoids
Quercetin
Rutin

Figure

• 

  Fig. 1. The activities of serum ALT in rats treated with ethanol. a,b Values in a bar without superscript letters denote significant difference (p < 0.05).

• 

  Fig. 2. The activities of serum AST in rats treated with ethanol. a,b,c Values in a bar without superscript letters denote significant difference (p < 0.05).

Reference

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