Int J Oral Biol.  2017 Jun;42(2):79-83. 10.11620/IJOB.2017.42.2.079.

Association between 14bp Insertion/Deletion Polymorphism in Exon 8 of HLA-G gene and Oral Squamous Cell Carcinoma in Korean Population

• Kang SW
• Ban JY

• KMID: 2385809
• DOI: http://doi.org/10.11620/IJOB.2017.42.2.079

Abstract

Abnormal HLA-G expression occurs in various diseases such as melanoma, renal cell carcinoma, asthma, and classic Hodgkin's lymphoma. The purpose of this study was to determine whether HLA-G gene is linked with oral squamous cell carcinoma (OSCC). To investigate the possible link with susceptibility to OSCC, 54 OSCC patients and 120 healthy controls were enrolled in this study. HLA-G 14bp insertion/deletion polymorphism is in 3"²-untranslated region of HLA-G gene. HLA-G 14bp insertion/deletion polymorphism was analyzed using the polymerase chain reaction (PCR) method. For the analysis of genetic data, SPSS18.0 program was used. Logistic regression models were performed for odds ratio (OR), 95 percent confidence interval (CI), and P value. There was a significant difference in distribution allele between OSCC patients and control subjects (OR=0.018, 95% CI=0.002-0.131, p<0.001). Our results suggest that HLA-G 14bp insertion/deletion polymorphism may be linked with susceptibility to OSCC in the Korean population.

Keyword

association study; oral squamous cell carcinoma; OSCC; HLA-G 14bp polymorphism

MeSH Terms

Alleles
Asthma
Carcinoma, Renal Cell
Carcinoma, Squamous Cell*
Epithelial Cells*
Exons*
HLA-G Antigens*
Hodgkin Disease
Humans
Logistic Models
Melanoma
Methods
Odds Ratio
Polymerase Chain Reaction
HLA-G Antigens