Kidney Res Clin Pract.  2017 Jun;36(2):200-204. 10.23876/j.krcp.2017.36.2.200.

Rapid deterioration of preexisting renal insufficiency after autologous mesenchymal stem cell therapy

• Kim JS
• Lee JH
• Kwon O
• Cho JH
• Choi JY
• Park SH
• Kim CD
• Kim YJ
• Kim YL

• KMID: 2384623
• DOI: http://doi.org/10.23876/j.krcp.2017.36.2.200

Abstract

Administration of autologous mesenchymal stem cells (MSCs) has been shown to improve renal function and histological findings in acute kidney injury (AKI) models. However, its effects in chronic kidney disease (CKD) are unclear, particularly in the clinical setting. Here, we report our experience with a CKD patient who was treated by intravenous infusion of autologous MSCs derived from adipose tissue in an unknown clinic outside of Korea. The renal function of the patient had been stable for several years before MSC administration. One week after the autologous MSC infusion, the preexisting renal insufficiency was rapidly aggravated without any other evidence of AKI. Hemodialysis was started 3 months after MSC administration. Renal biopsy findings at dialysis showed severe interstitial fibrosis and inflammatory cell infiltration, with a few cells expressing CD34 and CD117, 2 surface markers of stem cells. This case highlights the potential nephrotoxicity of autologous MSC therapy in CKD patients.

Keyword

Autologous transplantation; Chronic kidney disease; Mesenchymal stem cells

MeSH Terms

Acute Kidney Injury
Adipose Tissue
Biopsy
Dialysis
Fibrosis
Humans
Infusions, Intravenous
Korea
Mesenchymal Stromal Cells*
Renal Dialysis
Renal Insufficiency*
Renal Insufficiency, Chronic
Stem Cells
Transplantation, Autologous