J Audiol Otol.  2018 Apr;22(2):105-109. 10.7874/jao.2017.00150.

Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea. khpent@catholic.ac.kr
  • 2Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing.

Keyword

Sensorineural hearing loss; Bone marrow derived mesenchymal stem cell; Electrical stimulation

MeSH Terms

Animals
Bone Marrow
Clinical Study
Electric Stimulation
Hair
Hearing Loss*
Hearing Loss, Sensorineural
Hearing*
Humans
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stromal Cells*
Pilot Projects
Spiral Ganglion
Stem Cell Transplantation
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