Korean J Intern Med.
2015 Sep;30(5):719-726. 10.3904/kjim.2015.30.5.719.
Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population
- Affiliations
-
- 1Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea. jaeyong@knu.ac.kr
- 2Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
- 3Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
- KMID: 2381571
- DOI: http://doi.org/10.3904/kjim.2015.30.5.719
Abstract
- BACKGROUND/AIMS
A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean population.
METHODS
Ninety-four healthy individuals were enrolled in this study. Relative telomere length of chromosomes from peripheral blood samples was measured using quantitative polymerase chain reaction.
RESULTS
Two polymorphisms, rs10936599 of MYNN and rs412658 of ZNF676, were found to be associated w ith telomere length (under dominant model, p = 0.04; under recessive model, p = 0.001). Three polymorphisms, rs2853669, rs7705526, and rs2736108, at the TERT locus were also associated with telomere length (under recessive model, p = 0.01, p = 0.02, and p = 0.01, respectively). The genotypes of the five polymorphisms associated with short telomere length were considered bad genotypes; telomere length was significantly decreased with increasing number of bad genotypes (p= 1.7 x 10(-5)).
CONCLUSIONS
We have identified polymorphisms associated with telomere length in a Korean population.
Keyword
MeSH Terms
-
Adult
Aged
Asian Continental Ancestry Group/*genetics
Case-Control Studies
DNA-Binding Proteins/genetics
Female
Genome-Wide Association Study
Genotype
Humans
Kruppel-Like Transcription Factors/genetics
Male
Middle Aged
Phenotype
*Polymorphism, Single Nucleotide
Republic of Korea
Telomerase/genetics
Telomere/*genetics/metabolism
*Telomere Homeostasis
Zinc Fingers
DNA-Binding Proteins
Kruppel-Like Transcription Factors
Telomerase
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