Korean J Med.
2008 Nov;75(5):515-524.
Genetic susceptibility factors of rheumatoid arthritis
- Affiliations
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- 1Division of Rheumatology, Department of Internal Medicine, Hanyang University College of Medicine, Guri, Korea.
Abstract
- Rheumatoid arthritis (RA) is a chronic autoimmune disease that mainly involves the joints. Although the full etiology remains unclear, both genetic and environmental factors contribute to disease. Recently, genetic studies of RA, which include whole-genome linkage study, candidate gene association study, and especially genome-wide association study, made much progress through the advances in technology and large collection of case-controls. These various approaches provided new susceptible genes such as PTPN22, PADI4, STAT4, TNFAIP3, TRAF1-C5, CD40 gene in addition to HLA-DRB1. This review will cover an update in recent progress in RA genetics, focusing mainly on the several novel loci.
