J Cancer Prev.
2015 Sep;20(3):193-201. 10.15430/JCP.2015.20.3.193.
Chemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APC(Min/+) Intestinal Polyposis Model
- Affiliations
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- 1Department of Food and Nutrition Education, Graduate School of Education, Soonchunhyang University, Asan, Korea.
- 2Department of Food and Nutrition, College of Human Ecology, Sookmyung Women's University, Seoul, Korea. mksung@sm.ac.kr
- 3Department of Animal Science and Biotechnology, The Graduate School of Kyungpook National University, Daegu, Korea.
- 4National Yeongnam Agricultural Experiment Station, Rural Development Administration, Miryang, Korea.
- KMID: 2380870
- DOI: http://doi.org/10.15430/JCP.2015.20.3.193
Abstract
- BACKGROUND
Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was to investigate the effects of an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis.
METHODS
APC(Min/+) mice were fed a diet of 0.2% or 0.5% AE for 7 weeks. We analyzed the number of intestinal tumors, oxidative stress and inflammatory markers associated with beta-catenin and cytosolic phospholipase A2 (cPLA2) signals. The number of intestinal tumors, and cellular expression of beta-catenin were determined.
RESULTS
The number of intestinal tumors was significantly lower in mice fed a 0.5% AE diet compared to those of the other groups. Cytosolic beta-catenin expression was significantly decreased in the AE supplemented groups compared to that of the control animals. In addition, mucosa expression of cyclooxygenase-2 and cPLA2 were also significantly decreased in the 0.5% AE group, by 32% and 62%, respectively, compared to the control group.
CONCLUSIONS
These results suggest that dietary AE reduced the development of intestinal tumors, possibly through the ability to suppress oxidative stresses, decreasing inflammatory responses mediated by beta-catenin associated signals.
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