J Cancer Prev.  2017 Sep;22(3):135-146. 10.15430/JCP.2017.22.3.135.

Cancer-preventive Properties of an Anthocyanin-enriched Sweet Potato in the APCMIN Mouse Model

• Asadi K
• Ferguson L
• Philpott M
• Karunasinghe N

• KMID: 2396162
• DOI: http://doi.org/10.15430/JCP.2017.22.3.135

Abstract

BACKGROUND
Anthocyanin-rich foods and preparations have been reported to reduce the risk of life-style related diseases, including cancer. The SL222 sweet potato, a purple-fleshed cultivar developed in New Zealand, accumulates high levels of anthocyanins in its storage root.
METHODS
We examined the chemopreventative properties of the SL222 sweet potato in the C57BL/6J-APC(MIN/+) (APC(MIN)) mouse, a genetic model of colorectal cancer. APC(MIN) and C57BL/6J wild-type mice (n=160) were divided into four feeding groups consuming diets containing 10% SL222 sweet potato flesh, 10% SL222 sweet potato skin, or 0.12% ARE (Anthocyanin rich-extract prepared from SL222 sweet potato at a concentration equivalent to the flesh-supplemented diet) or a control diet (AIN-76A) for 18 weeks. At 120 days of age, the mice were anaesthetised, and blood samples were collected before the mice were sacrificed. The intestines were used for adenoma enumeration.
RESULTS
The SL222 sweet potato-supplemented diets reduced the adenoma number in the APC(MIN) mice.
CONCLUSIONS
These data have significant implications for the use of this sweet potato variant in protection against colorectal cancer.

Keyword

Anthocyanins; Sweet potato; Colorectal cancer; APCMIN mice; cancer Protection

MeSH Terms

Adenoma
Animals
Anthocyanins
Colorectal Neoplasms
Diet
Intestines
Ipomoea batatas*
Mice*
Models, Genetic
New Zealand
Skin
Anthocyanins