Biomol Ther.
2015 Mar;23(2):165-173. 10.4062/biomolther.2014.130.
Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
- Affiliations
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- 1Jeju National University School of Medicine, Jeju 690-756, Republic of Korea. jinwonh@jejunu.ac.kr
- 2Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan 614-052, Republic of Korea.
- 3Aging Research Center, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
- KMID: 2380350
- DOI: http://doi.org/10.4062/biomolther.2014.130
Abstract
- Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.
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