Int J Arrhythm.  2017 Mar;18(1):6-15. 10.18501/arrhythmia.2017.001.

Design of Korean Noninvasive Risk Evaluation Study for Sudden Cardiac Death from Infarction or Heart Failure: Myocardial infarction study of K-REDEFINE registry

  • 1Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • 2Ajou University Hospital, Suwon, Republic of Korea.
  • 3Asan Medical Center, Seoul, Republic of Korea.
  • 4Chonnam National University Hospital, Gwangju, Republic of Korea.
  • 5Chosun university hospital, Gwangju, Republic of Korea.
  • 6Chung-Ang University Hospital, Seoul, Republic of Korea.
  • 7Chungbuk National University Hospital, Cheongju, Republic of Korea.
  • 8Chungnam National University Hospital, Daejeon, Republic of Korea.
  • 9Daegu Catholic University Medical Center, Daegu, Republic of Korea.
  • 10Gachon University Gil Medical Center, Incheon, Republic of Korea.
  • 11Gangnam Severance Hospital, Seoul, Republic of Korea.
  • 12Inha university hospital, Incheon, Republic of Korea.
  • 13Inje University Busan Paik Hospital, Busan, Republic of Korea.
  • 14Inje University Ilsan Paik Hospital, Goyang, Republic of Korea.
  • 15International St. Mary's Hospital, Incheon, Republic of Korea.
  • 16Jeju National University Hospital, Jeju, Republic of Korea.
  • 17Keimyung university dongsan medical center, Daegu, Republic of Korea.
  • 18Korea University Medical Center, Seoul, Republic of Korea.
  • 19Korea University Ansan Hospital, Ansan, Republic of Korea.
  • 20Kosin University Gospel Hospital, Busan, Republic of Korea.
  • 21Sejong General Hospital, Bucheon, Republic of Korea.
  • 22Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • 23Wonkwang University Hospital, Iksan, Republic of Korea.
  • 24Wonju Severance Christian Hospital, Wonju, Republic of Korea.
  • 25Yeungnam University Hospital, Daegu, Republic of Korea.


Despite significant advances in the treatment of acute myocardial infarction (MI), the prevention of sudden cardiac death (SCD), the most common mode of death in patients with MI, remains challenging. Furthermore, previous Korean MI registries did not address the issue of post-MI SCD. Additional risk stratifiers of post-MI SCD are still required to compensate for the limitation of using left ventricular ejection fraction to predict lethal arrhythmic events.
We designed the first Korean prospective nationwide multicenter registry primarily focused on SCD; the Korean noninvasive Risk Evaluation study for sudden cardiac DEath From INfarction or heart failurE (K-REDEFINE). The registry consists of 2 groups of patients presenting with (1) acute MI or (2) acute heart failure (HF) at 25 tertiary referral cardiovascular centers. The primary endpoint of the MI group study of K-REDEFINE registry is the incidence and risk factors of post-MI SCD. In particular, the association between the risk of SCD and non-invasive Holter-based electrocardiogram (ECG) variables will be evaluated, such as T-wave alternans (marker of repolarization heterogeneity) and heart rate turbulence/variability (a marker of autonomic function). Other secondary study outcomes include atrioventricular arrhythmias, HF-related admission, repeated myocardial ischemic events, stroke, and overall deaths.
AND PERSPECTIVE: The K-REDEFINE registry will provide new prospects for the better management of MI patients with high risk of SCD by clarifying the burden and predictors of SCD and the clinical utility of various non-invasive ambulatory ECG-based variables in risk stratification for SCD in this patient population.


Sudden Cardiac Death; Myocardial Infarction; Electrocardiography; Ambulatory

MeSH Terms

Arrhythmias, Cardiac
Death, Sudden, Cardiac*
Heart Failure*
Heart Rate
Myocardial Infarction*
Prospective Studies
Referral and Consultation
Risk Factors
Stroke Volume
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