Int J Arrhythm.  2016 Dec;17(4):181-189. 10.18501/arrhythmia.2016.031.

Design of Korean Noninvasive Risk Evaluation Study for Sudden Cardiac Death from Infarction or Heart Failure: Heart failure study of K-REDEFINE registry

  • 1Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
  • 2Ajou University Hospital, Suwon, Republic of Korea.
  • 3Asan Medical Center, Seoul, Republic of Korea.
  • 4Chonnam National University Hospital, Gwangju, Republic of Korea.
  • 5Chosun university hospital, Gwangju, Republic of Korea.
  • 6Chung-Ang University Hospital, Seoul, Republic of Korea.
  • 7Chungbuk National University Hospital, Cheongju, Republic of Korea.
  • 8Chungnam National University Hospital, Daejeon, Republic of Korea.
  • 9Daegu Catholic University Medical Center, Daegu, Republic of Korea.
  • 10Gachon University Gil Medical Center, Incheon, Republic of Korea.
  • 11Gangnam Severance Hospital, Seoul, Republic of Korea.
  • 12Inha university hospital, Incheon, Republic of Korea.
  • 13Inje University Busan Paik Hospital, Busan, Republic of Korea.
  • 14Inje University Ilsan Paik Hospital, Goyang, Republic of Korea.
  • 15International St. Mary's Hospital, Incheon, Republic of Korea.
  • 16Jeju National University Hospital, Jeju, Republic of Korea.
  • 17Keimyung university dongsan medical center, Daegu, Republic of Korea.
  • 18Korea University Medical Center, Seoul, Republic of Korea.
  • 19Korea University Ansan Hospital, Ansan, Republic of Korea.
  • 20Kosin University Gospel Hospital, Busan, Republic of Korea.
  • 21Sejong General Hospital, Bucheon, Republic of Korea.
  • 22Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • 23Wonkwang University Hospital, Iksan, Republic of Korea.
  • 24Wonju Severance Christian Hospital, Wonju, Republic of Korea.
  • 25Yeungnam University Hospital, Daegu, Republic of Korea.


Sudden cardiac death (SCD) is one of the most common causes of death in patients with heart failure (HF). However, there are no available data on SCD in previous Korean HF registries. Additionally, although widely used, the utility of left ventricular (LV) ejection fraction (EF) in risk stratification for SCD is limited.
The Korean non-invasive Risk Evaluation study for sudden cardiac DEath From INfarction or heart failurE (KREDEFINE) is the first Korean prospective, nationwide multicenter registry, primarily focused on SCD. The registry consists of 2 groups of patients presenting with (1) acute HF or (2) acute myocardial infarction (MI) at 25 tertiary referral cardiovascular centers. Using the HF-group data of the K-REDEFINE registry, the incidence and risk factors of SCD in patients with HF will be assessed. In particular, the efficacy of Holter-based ECG variables, such as T-wave alternans (marker of repolarization heterogeneity) and heart rate turbulence/ variability (maker of autonomic function), in risk stratification for SCD will be evaluated. Other cardiovascular outcomes will also be analyzed, including atrioventricular arrhythmias, HF-related admission, stroke, and overall deaths.
AND PERSPECTIVE: The K-REDEFINE registry will pave the way for better management of patients with HF at high risk of SCD by elucidating the burden and risk factors of SCD and the clinical utility of various non-invasive ambulatory ECG-based parameters in risk stratification for SCD in this patient population.


Sudden Cardiac Death; Heart Failure; Electrocardiography; Ambulatory

MeSH Terms

Arrhythmias, Cardiac
Cause of Death
Death, Sudden, Cardiac*
Heart Failure*
Heart Rate
Myocardial Infarction
Prospective Studies
Referral and Consultation
Risk Factors
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