Int J Arrhythm.  2016 Dec;17(4):181-189. 10.18501/arrhythmia.2016.031.

Design of Korean Noninvasive Risk Evaluation Study for Sudden Cardiac Death from Infarction or Heart Failure: Heart failure study of K-REDEFINE registry

• Park SJ
• Hwang GS
• Nam GB
• Park HW
• Chung JW
• Shin SY
• Kim SM
• Kim JH
• Lee YS
• Park YM
• Kim JY
• Kim DH
• Kim DK
• Namgung J
• Shin DH
• Choi JH
• Park HS
• Choi JI
• Kim JS
• Cha TJ
• Park SW
• Uhm JS
• Kim NH
• Ahn M
• Shin DG
• Jang N
• Park M
• Kim JS
• K-REDEFINE investigators

• KMID: 2366165
• DOI: http://doi.org/10.18501/arrhythmia.2016.031

Abstract

BACKGROUND AND OBJECTIVES
Sudden cardiac death (SCD) is one of the most common causes of death in patients with heart failure (HF). However, there are no available data on SCD in previous Korean HF registries. Additionally, although widely used, the utility of left ventricular (LV) ejection fraction (EF) in risk stratification for SCD is limited.
SUBJECTS AND METHODS
The Korean non-invasive Risk Evaluation study for sudden cardiac DEath From INfarction or heart failurE (KREDEFINE) is the first Korean prospective, nationwide multicenter registry, primarily focused on SCD. The registry consists of 2 groups of patients presenting with (1) acute HF or (2) acute myocardial infarction (MI) at 25 tertiary referral cardiovascular centers. Using the HF-group data of the K-REDEFINE registry, the incidence and risk factors of SCD in patients with HF will be assessed. In particular, the efficacy of Holter-based ECG variables, such as T-wave alternans (marker of repolarization heterogeneity) and heart rate turbulence/ variability (maker of autonomic function), in risk stratification for SCD will be evaluated. Other cardiovascular outcomes will also be analyzed, including atrioventricular arrhythmias, HF-related admission, stroke, and overall deaths.
CONCLUSION
AND PERSPECTIVE: The K-REDEFINE registry will pave the way for better management of patients with HF at high risk of SCD by elucidating the burden and risk factors of SCD and the clinical utility of various non-invasive ambulatory ECG-based parameters in risk stratification for SCD in this patient population.

Keyword

Sudden Cardiac Death; Heart Failure; Electrocardiography; Ambulatory

MeSH Terms

Arrhythmias, Cardiac
Cause of Death
Death, Sudden, Cardiac*
Electrocardiography
Heart Failure*
Heart Rate
Heart*
Humans
Incidence
Infarction*
Myocardial Infarction
Prospective Studies
Referral and Consultation
Registries
Risk Factors
Stroke