Nat Prod Sci.  2017 Mar;23(1):61-68. 10.20307/nps.2017.23.1.61.

Anti-obesity Effect of Steamed Soybean and Fermented Steamed Soybean in High-fat Diet-induced Obese ICR Mice

• Seo HR
• Lee AY
• Cho KM
• Cho EJ
• Kim HY

• KMID: 2376501
• DOI: http://doi.org/10.20307/nps.2017.23.1.61

Abstract

This study was performed to investigate the ameliorating effects of steamed soybeans (SS) and fermented SS (FSS) on lipid metabolism in high-fat diet-induced obese mice. ICR mice were divided into four groups and given the following different diets: normal diet (ND), high-fat diet (HFD), HFD with 1% SS (HFD + SS), and HFD with 1% FSS (HFD + FSS). After 14 weeks, the body weight gain was higher in the HFD group compared with the ND group but lower in the HFD + FSS group compared with the HFD group. Plasma levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were significantly higher in the HFD group compared to the ND group, but lower in the HFD + SS and HFD + FSS groups compared with the HFD group. In addition, leptin concentration in plasma was lower in the groups fed HFD + SS and HFD + FSS compared with the HFD group. The accumulation of hepatic TG and TC was significantly inhibited in the HFD + SS and HFD + FSS groups. Furthermore, SS and FSS attenuated lipid peroxidation and nitric oxide formation in the liver induced by the high-fat diet. These results suggest that soybeans, especially FSS, may be useful in preventing obesity-induced abnormalities in lipid metabolism.

Keyword

Obesity; Soybean; High-fat diet; Lipid metabolism; Oxidative stress

MeSH Terms

Alanine Transaminase
Animals
Aspartate Aminotransferases
Body Weight
Cholesterol
Diet
Diet, High-Fat
Leptin
Lipid Metabolism
Lipid Peroxidation
Liver
Mice
Mice, Inbred ICR*
Mice, Obese
Nitric Oxide
Obesity
Oxidative Stress
Plasma
Soybeans*
Steam*
Triglycerides
Alanine Transaminase
Aspartate Aminotransferases
Cholesterol
Leptin
Nitric Oxide
Steam

Figure

• 

  Fig. 1. Effects of SS and FSS on AST (A) and ALT (B) levels. Values are mean ± SD (n = 6). a∼dMeans indicated with different letters are significantly different (P < 0.05) by Duncan's multiple range test. ND: normal diet, HFD: high-fat diet, SS: 1% steamed soybean, FSS: 1% steamed soybean fermented for 60 h.

• 

  Fig. 2. Effects of SS and FSS on plasma leptin. Values are mean ± SD (n = 6). a∼cMeans indicated with different letters are significantly different (P < 0.05) by Duncan's multiple range test. ND: normal diet, HFD: high-fat diet, SS: 1% steamed soybean, FSS: 1% steamed soybean fermented for 60 h.

• 

  Fig. 3. Effects of SS and FSS on hepatic TG (A) and TC (B). Values are mean ± SD (n = 6). a∼bMeans indicated with different letters are significantly different (P < 0.05) by Duncan's multiple range test. ND: normal diet, HFD: high-fat diet, SS: 1% steamed soybean, FSS: 1% steamed soybean fermented for 60 h.

Reference

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