J Nutr Health.  2013 Dec;46(6):493-502.

Effect of fermented soybean curd residue (FSCR; SCR-meju) by aspergillus oryzae on the anti-obesity and lipids improvement

• Lee SI
• Lee YK
• Kim SD
• Lee JE
• Choi J
• Bak JP
• Lim JH
• Suh JW
• Lee IA

Abstract

In this study, we designed to confirm the dietary effect of anti-obesity of fermented soybean curd residue (FSCR; SCR-Meju; Biji-meju) by A. oryzae, which is well known as a Korean traditional meju microbe. We observed that body weight gain, serum and hepatic lipid profile, as well as the activity of ROS generating enzyme and ROS scavenging enzyme in high-fat diet induced obese mice fed experimental diet (SCR and SCR-meju). Body weight gain and epididymal fat weight of HC (high-fat diet control) was markedly higher than that of NC (Normal control). Conversely, body weight gain and epididymal fat weight of the SCR (Biji) and SCR-meju (Biji-meju) group was significantly lower than that of HC; these of the SCR-meju group was lower than that of the SCR group. Furthermore, serum TG and total-cholesterol and LDL-cholesterol contents of SCR and SCR-meju groups were lower than that of HC, and HDL-cholesterol level of the SCR-meju group was significantly higher than that of HC. In conclusion, although precise mechanisms of the antiobese effects of SCR-meju in this study are unknown, the present study provides an experimental evidence that SCR-meju may prevent obesity and obesity related metabolic syndromes, such as hyperlipidemia, hypertension and diabetes, and liver disease by high-fat diet. Nevertheless, further study in this filed will be needed.

Keyword

soybean curd residue (SCR, biji); aspergillus oryzae; SCR-meju (biji-meju); anit-obesity; antioxidant enzymes

MeSH Terms

Animals
Aspergillus oryzae*
Aspergillus*
Body Weight
Diet
Diet, High-Fat
Hyperlipidemias
Hypertension
Liver Diseases
Mice
Mice, Obese
Obesity
Oryza
Soybeans*

Figure

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  Fig. 1. Preparation procedure of fermented soybean curd residue (SCR-meju).

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  Fig. 2. Effects of SCR and SCR-meju supplemented high fat diets on the changes in body weight gain (% against initial) of mouse fed for 8 weeks. See Fig. 1 and Table 1. Values are means (n = 6), and the values of the final week are mean ± standard deviations (n = 6). Different superscripts on the final week indicate significant differences (p ＜ 0.05).

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  Fig. 3. Effects of FSCR supplemented diets on the weight of fat around epididymis in mouse fed for 8 weeks. See Table 1. Values are mean ± standard deviations (n = 5), different superscripts in the figures indicates significant differences (p ＜ 0.05).

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  Fig. 4. Effects of SCR and SCR-meju supplemented high fat diets on the content of hepatic TG and TC in mouse fed for 8 weeks. See Table 1. Values are mean ± standard deviations (n = 5), different superscripts in the figures indicates significant differences (p ＜ 0.05).

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  Fig. 5. Effects of SCR and SCR-meju supplemented high fat diets on the content of glutathione total lipid peroxide in mouse fed for 8 weeks. See Table 1. Values are mean ± standard deviations (n = 5), different superscripts in the figures indicates significant differences (p ＜ 0.05).

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  Fig. 6. Effects of SCR and SCR-meju supplemented high fat diets on the serum ALT activity in mouse fed for 8 weeks. See Table 1. Values are mean ± standard deviations (n = 5), different superscripts in the figures indicates significant differences (p ＜ 0.05).

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  Fig. 7. Effects of SCR and SCR-meju supplemented high fat diets on the activities of XO, SOD, GPX and GST in liver of mouse fed for 8 weeks. See Table 1. Values are mean ± standard deviations (n = 5), different superscripts in the figures indicates significant differences (p ＜ 0.05).

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  Fig. 8. Light microscopic photographs of liver tissue (bar: 25 µ m) of mouse fed with experimental diets for 8 weeks (HE stain). The hepatocytes in HC group are distended by accumulation of multiple fat droplets and sinusoids are occluded (arrow).

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