J Gastric Cancer.  2014 Jun;14(2):67-86.

Mouse Models of Gastric Carcinogenesis

• Yu S
• Yang M
• Nam KT

Abstract

Gastric cancer is one of the most common cancers in the world. Animal models have been used to elucidate the details of the molecular mechanisms of various cancers. However, most inbred strains of mice have resistance to gastric carcinogenesis. Helicobacter infection and carcinogen treatment have been used to establish mouse models that exhibit phenotypes similar to those of human gastric cancer. A large number of transgenic and knockout mouse models of gastric cancer have been developed using genetic engineering. A combination of carcinogens and gene manipulation has been applied to facilitate development of advanced gastric cancer; however, it is rare for mouse models of gastric cancer to show aggressive, metastatic phenotypes required for preclinical studies. Here, we review current mouse models of gastric carcinogenesis and provide our perspectives on future developments in this field.

Keyword

Stomach neoplasms; Helicobacter infections; Mouse model

MeSH Terms

Animals
Carcinogenesis*
Carcinogens
Genetic Engineering
Helicobacter Infections
Humans
Mice*
Mice, Inbred Strains
Mice, Knockout
Models, Animal
Phenotype
Stomach Neoplasms
Carcinogens

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