J Cancer Prev.  2015 Jun;20(2):92-96. 10.15430/JCP.2015.20.2.92.

Anticancer Effect of Lycopene in Gastric Carcinogenesis

• Kim MJ
• Kim H

• KMID: 2171333
• DOI: http://doi.org/10.15430/JCP.2015.20.2.92

Abstract

Gastric cancer ranks as the most common cancer and the second leading cause of cancer-related death in the world. Risk factors of gastric carcinogenesis include oxidative stress, DNA damage, Helicobacter pylori infection, bad eating habits, and smoking. Since oxidative stress is related to DNA damage, smoking, and H. pylori infection, scavenging of reactive oxygen species may be beneficial for prevention of gastric carcinogenesis. Lycopene, one of the naturally occurring carotenoids, has unique structural and chemical features that contributes to a potent antioxidant activity. It shows a potential anticancer activity and reduces gastric cancer incidence. This review will summarize anticancer effect and mechanism of lycopene on gastric carcinogenesis based on the recent experimental and clinical studies.

Keyword

Anticancer effect; Lycopene; Gastric carcinogenesis

MeSH Terms

Carcinogenesis*
Carotenoids
DNA Damage
Eating
Helicobacter pylori
Incidence
Oxidative Stress
Reactive Oxygen Species
Risk Factors
Smoke
Smoking
Stomach Neoplasms
Carotenoids
Reactive Oxygen Species
Smoke