J Bone Metab.  2016 Nov;23(4):183-190. 10.11005/jbm.2016.23.4.183.

Association of Serum Osteocalcin with Insulin Resistance and Coronary Atherosclerosis

• Kang JH

• KMID: 2361579
• DOI: http://doi.org/10.11005/jbm.2016.23.4.183

Abstract

BACKGROUND
To determine the associations between serum osteocalcin level and insulin resistance, coronary atherosclerosis by using dual-source coronary computed tomography angiography.
METHODS
A total of 98 subjects (24 men and 74 women) were selected for this retrospective cross-sectional study who voluntarily visited a health examination center for routine health check-up including the blood test for serum osteocalcin level and coronary computed tomography angiography. Multiple regression analysis was used to determine which variables were independently related to osteocalcin levels and coronary atherosclerosis.
RESULTS
Stepwise multiple regression analysis adjusted for age, sex, menopausal status, body mass index, serum alkaline phosphatase, serum calcium and phosphate showed that osteocalcin negatively correlated with serum glucose (β=-0.145, P=0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) index (β=-1.794, P=0.027) independently. The age, serum glucose, smoking status but not osteocalcin level were independent risk factors for coronary atherosclerosis by use of multiple logistic regression analysis after controlling for other variables.
CONCLUSIONS
Serum osteocalcin level was inversely associated with fasting glucose level and insulin resistance measured by HOMA-IR, suggesting that osteocalcin is important for glucose metabolism. However, in this study, no significant difference was observed in the serum osteocalcin level according to the presence of coronary atherosclerotic plaques.

Keyword

Coronary angiography; Coronary artery disease; Insulin resistance; Osteocalcin

MeSH Terms

Alkaline Phosphatase
Angiography
Blood Glucose
Body Mass Index
Calcium
Coronary Angiography
Coronary Artery Disease*
Cross-Sectional Studies
Fasting
Glucose
Hematologic Tests
Homeostasis
Humans
Insulin Resistance*
Insulin*
Logistic Models
Male
Metabolism
Osteocalcin*
Plaque, Atherosclerotic
Retrospective Studies
Risk Factors
Smoke
Smoking
Alkaline Phosphatase
Calcium
Glucose
Insulin
Osteocalcin
Smoke

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