J Bone Metab.  2016 Nov;23(4):183-190. 10.11005/jbm.2016.23.4.183.

Association of Serum Osteocalcin with Insulin Resistance and Coronary Atherosclerosis

Affiliations
  • 1Department of Family Medicine, Konyang University Hospital, Daejeon, Korea. jeehyunkang@yahoo.co.kr

Abstract

BACKGROUND
To determine the associations between serum osteocalcin level and insulin resistance, coronary atherosclerosis by using dual-source coronary computed tomography angiography.
METHODS
A total of 98 subjects (24 men and 74 women) were selected for this retrospective cross-sectional study who voluntarily visited a health examination center for routine health check-up including the blood test for serum osteocalcin level and coronary computed tomography angiography. Multiple regression analysis was used to determine which variables were independently related to osteocalcin levels and coronary atherosclerosis.
RESULTS
Stepwise multiple regression analysis adjusted for age, sex, menopausal status, body mass index, serum alkaline phosphatase, serum calcium and phosphate showed that osteocalcin negatively correlated with serum glucose (β=-0.145, P=0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) index (β=-1.794, P=0.027) independently. The age, serum glucose, smoking status but not osteocalcin level were independent risk factors for coronary atherosclerosis by use of multiple logistic regression analysis after controlling for other variables.
CONCLUSIONS
Serum osteocalcin level was inversely associated with fasting glucose level and insulin resistance measured by HOMA-IR, suggesting that osteocalcin is important for glucose metabolism. However, in this study, no significant difference was observed in the serum osteocalcin level according to the presence of coronary atherosclerotic plaques.

Keyword

Coronary angiography; Coronary artery disease; Insulin resistance; Osteocalcin

MeSH Terms

Alkaline Phosphatase
Angiography
Blood Glucose
Body Mass Index
Calcium
Coronary Angiography
Coronary Artery Disease*
Cross-Sectional Studies
Fasting
Glucose
Hematologic Tests
Homeostasis
Humans
Insulin Resistance*
Insulin*
Logistic Models
Male
Metabolism
Osteocalcin*
Plaque, Atherosclerotic
Retrospective Studies
Risk Factors
Smoke
Smoking
Alkaline Phosphatase
Calcium
Glucose
Insulin
Osteocalcin
Smoke

Cited by  1 articles

Association of Insulin Resistance with Lower Bone Volume and Strength Index of the Proximal Femur in Nondiabetic Postmenopausal Women
Jaewon Yang, Namki Hong, Jee-Seon Shim, Yumie Rhee, Hyeon Chang Kim
J Bone Metab. 2018;25(2):123-132.    doi: 10.11005/jbm.2018.25.2.123.


Reference

1. Kanazawa I. Osteocalcin as a hormone regulating glucose metabolism. World J Diabetes. 2015; 6:1345–1354.
Article
2. Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007; 130:456–469.
Article
3. Ferron M, Hinoi E, Karsenty G, et al. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A. 2008; 105:5266–5270.
Article
4. Kindblom JM, Ohlsson C, Ljunggren O, et al. Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res. 2009; 24:785–791.
Article
5. Fernández-Real JM, Izquierdo M, Ortega F, et al. The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab. 2009; 94:237–245.
Article
6. Choi BH, Joo NS, Kim MJ, et al. Coronary artery calcification is associated with high serum concentration of undercarboxylated osteocalcin in asymptomatic Korean men. Clin Endocrinol (Oxf). 2015; 83:320–326.
Article
7. Kim KJ, Kim KM, Park KH, et al. Aortic calcification and bone metabolism: the relationship between aortic calcification, BMD, vertebral fracture, 25-hydroxyvitamin D, and osteocalcin. Calcif Tissue Int. 2012; 91:370–378.
Article
8. Sheng L, Cao W, Cha B, et al. Serum osteocalcin level and its association with carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol. 2013; 12:22.
Article
9. Yang R, Ma X, Dou J, et al. Relationship between serum osteocalcin levels and carotid intima-media thickness in Chinese postmenopausal women. Menopause. 2013; 20:1194–1199.
Article
10. Hwang YC, Kang M, Cho IJ, et al. Association between the circulating total osteocalcin level and the development of cardiovascular disease in middle-aged men: a mean 8.7-year longitudinal follow-up study. J Atheroscler Thromb. 2015; 22:136–143.
Article
11. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28:412–419.
Article
12. Hong SH, Koo JW, Hwang JK, et al. Changes in serum osteocalcin are not associated with changes in glucose or insulin for osteoporotic patients treated with bisphosphonate. J Bone Metab. 2013; 20:37–41.
Article
13. Atalay S, Elci A, Kayadibi H, et al. Diagnostic utility of osteocalcin, undercarboxylated osteocalcin, and alkaline phosphatase for osteoporosis in premenopausal and postmenopausal women. Ann Lab Med. 2012; 32:23–30.
Article
14. Leung KS, Fung KP, Sher AH, et al. Plasma bone-specific alkaline phosphatase as an indicator of osteoblastic activity. J Bone Joint Surg Br. 1993; 75:288–292.
Article
15. Gundberg CM, Looker AC, Nieman SD, et al. Patterns of osteocalcin and bone specific alkaline phosphatase by age, gender, and race or ethnicity. Bone. 2002; 31:703–708.
Article
16. Lee SW, Jo HH, Kim MR, et al. Association between obesity, metabolic risks and serum osteocalcin level in postmenopausal women. Gynecol Endocrinol. 2012; 28:472–477.
Article
17. Kim SH, Lee JW, Im JA, et al. Serum osteocalcin is related to abdominal obesity in Korean obese and overweight men. Clin Chim Acta. 2010; 411:2054–2057.
Article
18. Oosterwerff MM, van Schoor NM, Lips P, et al. Osteocalcin as a predictor of the metabolic syndrome in older persons: a population-based study. Clin Endocrinol (Oxf). 2013; 78:242–247.
Article
19. Zanatta LC, Boguszewski CL, Borba VZ, et al. Osteocalcin, energy and glucose metabolism. Arq Bras Endocrinol Metabol. 2014; 58:444–451.
Article
20. Tankò LB, Bagger YZ, Christiansen C. Low bone mineral density in the hip as a marker of advanced atherosclerosis in elderly women. Calcif Tissue Int. 2003; 73:15–20.
Article
21. Trivedi DP, Khaw KT. Bone mineral density at the hip predicts mortality in elderly men. Osteoporos Int. 2001; 12:259–265.
Article
22. Confavreux CB, Szulc P, Casey R, et al. Higher serum osteocalcin is associated with lower abdominal aortic calcification progression and longer 10-year survival in elderly men of the MINOS cohort. J Clin Endocrinol Metab. 2013; 98:1084–1092.
Article
23. Zhang Y, Qi L, Gu W, et al. Relation of serum osteocalcin level to risk of coronary heart disease in Chinese adults. Am J Cardiol. 2010; 106:1461–1465.
Article
24. Evrard S, Delanaye P, Kamel S, et al. Vascular calcification: from pathophysiology to biomarkers. Clin Chim Acta. 2015; 438:401–414.
Article
25. Flammer AJ, Gössl M, Widmer RJ, et al. Osteocalcin positive CD133+/CD34−/KDR+ progenitor cells as an independent marker for unstable atherosclerosis. Eur Heart J. 2012; 33:2963–2969.
Article
26. Patti A, Gennari L, Merlotti D, et al. Endocrine actions of osteocalcin. Int J Endocrinol. 2013; 2013:846480.
Article
27. Montalcini T, Emanuele V, Ceravolo R, et al. Relation of low bone mineral density and carotid atherosclerosis in postmenopausal women. Am J Cardiol. 2004; 94:266–269.
Article
28. Luo Y, Ma X, Hao Y, et al. Relationship between serum osteocalcin level and carotid intima-media thickness in a metabolically healthy Chinese population. Cardiovasc Diabetol. 2015; 14:82.
Article
29. Yeap BB, Chubb SA, Flicker L, et al. Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study. Osteoporos Int. 2012; 23:599–606.
Article
30. Holvik K, van Schoor NM, Eekhoff EM, et al. Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study. Eur J Endocrinol. 2014; 171:161–170.
Article
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