Allergy Asthma Respir Dis.  2016 Mar;4(2):82-90. 10.4168/aard.2016.4.2.82.

Airway epithelial cells in airway inflammation and remodeling in asthma

Affiliations
  • 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. shkrins@gmail.com
  • 2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Abstract

Airway epithelial cells are the front-line barrier to outer world, and abnormal response to environmental agents can cause asthma. Large numbers of recent studies support the evidence that airway epithelial cells play a crucial role in the development of airway inflammation and remodeling. Defective barrier function of airway epithelium facilitates allergic sensitization and initiation of allergic inflammation. Airway epithelial cells contribute to the development of type 2 immune response by secreting key cytokines, such as interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin and the interactions between various innate immune cells, including innate lymphoid cells, granulocytes, and macrophages. Furthermore, airway remodeling can be induced by epithelial cell-derived mediators even independently of airway inflammation. Aberrant repair of airway injury or distinct biophysical/biochemical characteristics of airway epithelial cells in asthmatics may be involved in the pathophysiologic mechanism of airway remodeling. Therapeutic approaches targeting airway epithelial cells are warranted.

Keyword

Asthma; Epithelial cell; Remodeling

MeSH Terms

Airway Remodeling
Asthma*
Cytokines
Epithelial Cells*
Epithelium
Granulocytes
Inflammation*
Interleukins
Lymphocytes
Macrophages
Cytokines
Interleukins
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