Asia Pac Allergy.  2014 Jan;4(1):19-24. 10.5415/apallergy.2014.4.1.19.

Airway remodelling in asthma: role for mechanical forces

• Manuyakorn W

• KMID: 2397121
• DOI: http://doi.org/10.5415/apallergy.2014.4.1.19

Abstract

Asthma is a chronic airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness and airflow obstruction. Airway structural changes or airway remodelling consist of epithelial injury, goblet cell hyperplasia, subepithelial layer thickening, airway smooth muscle hyperplasia and angiogenesis. These changes were previously considered as a consequence of chronic airway inflammation. Even though inhaled corticosteroids can suppress airway inflammation, the natural history of asthma is still unaltered after inhaled corticosteroid treatment. As such there is increasing evidence for the role of mechanical forces within the asthmatic airway contributing to airway structural changes.

Keyword

Asthma; Airway remodelling; Mechanical forces

MeSH Terms

Adrenal Cortex Hormones
Airway Remodeling*
Asthma*
Goblet Cells
Hyperplasia
Inflammation
Muscle, Smooth
Natural History
Adrenal Cortex Hormones