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An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response

Park SC, Kim H, Bak Y, Shim D, Kwon KW, Kim CH, Yoon JH, Shin SJ

PURPOSE: Simple and reliable animal models of human diseases contribute to the understanding of disease pathogenesis as well as the development of therapeutic interventions. Although several murine models to mimic...
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A Lacrimal Punctal Keratinizing Cyst of the Lower Lid

Kang TS, Lee YH, Lee SB

PURPOSE: We report an unusual case of a keratinizing cyst on the lacrimal punctum. CASE SUMMARY: A 49-year-old female presented with an outpouching punctal mass at the left lower lid that...
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Effect of Pyunkang-tang on Inflammatory Aspects of Chronic Obstructive Pulmonary Disease in a Rat Model

Seo HS, Lee HJ, Lee CJ

We investigated the anti-inflammatory effect of Pyunkang-tang extract (PGT), a complex herbal extract based on traditional Chinese medicine that is used in Korea for controlling diverse pulmonary diseases, on cigarette...
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Antiallergic Effect of Hizikia fusiformis in an Ovalbumin-Induced Allergic Rhinitis Mouse Model

Zhang YL, Shin HJ, Lee JH, Lee J

OBJECTIVES: The extract of Hizikia fusiformis is known to exhibit anticancer, antiatopic and antioxidant activities. We aimed to investigate the extract of H. fusiformis on allergic rhinitis inflammation in a...
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Influence of Intranasal Drugs on Human Nasal Mucociliary Clearance and Ciliary Beat Frequency

Jiao J, Zhang L

The nasal mucociliary clearance system, which comprises epithelial cilia and mucus from goblet cells, is an important intrinsic defense mechanism of the upper respiratory tract. Intranasal drugs and additives can...
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Implication of Porphyromonas gingivalis in colitis and homeostasis of intestinal epithelium

Seo Y, Oh SJ, Ahn JS, Shin YY, Yang JW, Kim HS

Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, has...
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The Interplay between Host Immunity and Respiratory Viral Infection in Asthma Exacerbation

Hossain FM, Choi JY, Uyangaa E, Park SO, Eo SK

Asthma is one of the most common and chronic diseases characterized by multidimensional immune responses along with poor prognosis and severity. The heterogeneous nature of asthma may be attributed to...
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Histomorphometric demonstration of the effect of chronic use of nonsteroidal anti-inflammatory drugs–ibuprofen on mucosa of small intestine

Vaidya YP, Tarnekar A, Shende MR

The purpose of this study was to ascertain change in structure of mucosa of small intestine, if any, in small intestine of Swiss albino mice as an effect of chronic...
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TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model

Choi JY, Lee HY, Hur J, Kim KH, Kang JY, Rhee CK, Lee SY

PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1...
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Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model

Liang L, Hur J, Kang JY, Rhee CK, Kim YK, Lee SY

BACKGROUND/AIMS: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin...
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dNP2-ctCTLA-4 inhibits German cockroach extract-induced allergic airway inflammation and hyper-responsiveness via inhibition of Th2 responses

Lim S, Sohn JH, Koo JH, Park JW, Choi JM

German cockroaches are major household allergens that can trigger allergic airway inflammatory diseases with sensitive T-cell responses. Although the use of immune modulatory biologics, such as antibodies, to mediate allergic...
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Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release

Bui TT, Piao CH, Song CH, Lee CH, Shin HS, Chai OH

Asthma is characterized by chronic inflammation, goblet cell hyperplasia, the aberrant production of the Th2 cytokines, and eosinophil infiltration into the lungs. In this study, we examined the effects of...
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Morphology of cat vomeronasal organ non-sensory epithelium during postnatal development

Elgayar SA, Saad-Eldin HM, Haussein O

The vomeronasal organ has an important role in mammal's social and sexual behaviours. In addition, it mediates defensive behavior through detection of protein pheromone homologues. In this work, a detailed...
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Effect of Proparacaine in a Mouse Model of Allergic Rhinitis

Kim HS, Won S, Lee EK, Chun YH, Yoon JS, Kim JT, Kim HH

OBJECTIVES: Lidocaine, a local anaesthetic is a treatment option in uncontrolled asthma due to its immunomodulatory effects. In the present study, proparacaine (PPC), a derivative of lidocaine was examined for...
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Novel glutathione-containing dry-yeast extracts inhibit eosinophilia and mucus overproduction in a murine model of asthma

Kim YH, Choi YJ, Lee EJ, Kang MK, Park SH, Kim DY, Oh H, Park SJ, Kang YH

BACKGROUND/OBSECTIVE: Airway inflammation by eosinophils, neutrophils and alveolar macrophages is a characteristic feature of asthma that leads to pathological subepithelial thickening and remodeling. Our previous study showed that oxidative stress...
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Inhibitory Effects of Resveratrol on Airway Remodeling by Transforming Growth Factor-β/Smad Signaling Pathway in Chronic Asthma Model

Lee HY, Kim IK, Yoon HK, Kwon SS, Rhee CK, Lee SY

PURPOSE: Asthma is a chronic airway disease characterized by airway remodeling, leading to a progressive decline in lung function. Therapeutic agents that attenuate airway remodeling can complement the limited effects...
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Effect of combined sodium hyaluronate and carboxymethyl cellulose on ocular surface in rat dry eye model

Moon JG, Ku SK, Kwon YS

This study was conducted to evaluate three different mixed formulations of sodium hyaluronate (SH) and carboxymethyl cellulose (CMC) using a low-humidity air flow-induced rat dry eye model and determine the...
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Adenovirus-mediated Foxp3 expression in lung epithelial cells reduces airway inflammation in ovalbumin and cockroach-induced asthma model

Park S, Chung HS, Shin D, Jung KH, Lee H, Moon J, Bae H

Foxp3 is a master regulator of CD4⁺CD25⁺ regulatory T-cell (Treg) function and is also a suppressor of SKP2 and HER2/ErbB2. There are an increasing number of reports describing the functions...
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Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation

Takeda K, Miyahara N, Matsubara , Taube C, Kitamura K, Hirano A, Tanimoto M, Gelfand EW

Ambroxol is used in COPD and asthma to increase mucociliary clearance and regulate surfactant levels, perhaps through anti-oxidant and anti-inflammatory activities. To determine the role and effect of ambroxol in...
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CpG Oligodeoxynucleotide Inhibits Cockroach-Induced Asthma via Induction of IFN-gamma+ Th1 Cells or Foxp3+ Regulatory T Cells in the Lung

Kim DH, Sohn JH, Park HJ, Lee JH, Park JW, Choi JM

PURPOSE: CpG oligodeoxynucleotide (CpG-ODN), a TLR9 agonist, activates innate immunity and induces Th1 response. Although the immune modulatory effect of CpG-ODN has been extensively studied, its function in cockroach extract-induced...
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