Ann Coloproctol.  2015 Apr;31(2):74-78. 10.3393/ac.2015.31.2.74.

Peritoneal Metastatic Goblet-Cell Carcinoid Tumor Treated With Cytoreductive Surgery and Intraperitoneal Chemotherapy

• Youn SI
• Namgung H
• Yun JS
• Park YJ
• Park DG

• KMID: 1801588
• DOI: http://doi.org/10.3393/ac.2015.31.2.74

Abstract

We report a case of a goblet-cell carcinoid tumor of the appendix which metastasized to the peritoneum and was treated by using cytoreductive surgery (CRS) with intraperitoneal chemotherapy. A 47-year-old male presented with chronic constipation and was diagnosed as having a rectal adenocarcinoma with a signet-ring-cell component under colonoscopy. Computed tomography suggested peritoneal metastases with diffuse nodular parietal peritoneal thickening of the entire abdomen and focal invasion of the upper rectum by a seeding mass. CRS with intraperitoneal chemotherapy was done under the diagnosis of a rectal adenocarcinoma with peritoneal metastases. The pathologic diagnosis was a goblet-cell carcinoid tumor of the appendix with peritoneal metastasis. The histological discrepancy between a peritoneal metastatic mass and a rectal mass was due to the mixed histological pattern of a goblet-cell carcinoid tumor. A metastatic mass may not share identical immunohistochemical characteristics from its origin. This histologic discrepancy necessitates caution in diagnosing a distant metastasis of a goblet-cell carcinoid tumor.

Keyword

Appendix; Carcinoid tumor; Goblet cells; Peritoneal neoplasms; Intraperitoneal infusion

MeSH Terms

Abdomen
Adenocarcinoma
Appendix
Carcinoid Tumor*
Colonoscopy
Constipation
Diagnosis
Drug Therapy*
Goblet Cells
Humans
Infusions, Parenteral
Male
Middle Aged
Neoplasm Metastasis
Peritoneal Neoplasms
Peritoneum
Rabeprazole
Rectum