Allergy Asthma Respir Dis.  2016 Nov;4(6):423-428. 10.4168/aard.2016.4.6.423.

Association between the serum 25-hydroxyvitamin D level and allergic rhinitis in Korean children

• Yoon SH
• Kim JY
• Kim YH
• Park YA
• Sol IS
• Kim MJ
• Kim KW
• Sohn MH
• Kim KE

• KMID: 2361257
• DOI: http://doi.org/10.4168/aard.2016.4.6.423

Abstract

PURPOSE
Vitamin D is known to play an important role in the regulation of the immune system and in the prevention of allergic disease. Herein, we examined the association between vitamin D and allergic rhinitis (AR) in children.
METHODS
A total of 72 aeroallergen-proven AR and 57 healthy control subjects who visited Severance Children's Hospital between 2012 and 2014 were evaluated. The mean serum 25-hydroxyvitamin D (25(OH)D) level was measured in all subjects to evaluate their vitamin D status.
RESULTS
The mean serum 25(OH)D levels was significantly lower in patients with AR than in controls (19.5±6.4 ng/mL vs. 22.3±5.8 ng/mL, P=0.013). The incidence of AR is higher in the 25(OH)D-insufficient group (15-20 ng/mL) and in the 25(OH)D-deficient group (≤15 ng/mL) compared with the 25(OH)D-sufficient group (>20 ng/mL) (40.3% vs. 84.4% vs. 22.2%, P<0.001). There was no significant difference in the serum 25(OH)D level between subgroups with mild and moderate-to-severe AR symptoms (19.8±6.5 vs. 19.0±6.3, P=0.596). After adjusting for confounding factors, the lower serum vitamin D level groups had increased odds of AR compared with the 25(OH)D-sufficient group (odds ration [95% confidence interval]; 3.67 [1.29-10.38] in the 25(OH)D-insufficient group; P=0.014 and 6.04 [1.49-24.51] in the 25(OH)D-deficient group; P=0.012).
CONCLUSION
The serum vitamin D levels were significantly lower in children with AR compared with healthy controls. Therefore, lower serum level of 25(OH)D may be associated with the development of AR.

Keyword

Allergic rhinitis; Vitamin D; Childhood

MeSH Terms

Child*
Humans
Immune System
Incidence
Rhinitis, Allergic*
Vitamin D
Vitamin D

Figure

• 

  Fig. 1 Comparison of serum vitamin D levels according to the presence of allergic rhinitis (A) and the Allergic Rhinitis and its Impact on Asthma (ARIA) classification (B). (A) The box plots show the significant difference in the mean 25-hydroxyvitamin D (25(OH)D) levels between the allergic rhinitis and control group. (B) No significant differences were observed among the ARIA classification subgroups. Allergic rhinitis was classified on the basis of the ARIA 2008 guideline. Data are expressed as mean±standard deviation.

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