Tissue Eng Regen Med.
2016 Apr;13(2):200-209. 10.1007/s13770-016-9125-y.
Autologous Bone Marrow Mesenchymal Cell Induced Chondrogenesis for the Treatment of Osteoarthritis of Knee
- Affiliations
-
- 1Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea. peter@catholic.ac.kr
- 2Canterbury Christ Church University, Institute of Medical Sciences, Faculty of Health and Wellbeing, Kent, United Kingdom.
- 3Department of Health Administration, College of Health Science, Dankook University, Cheonan, Korea. jangmook@gmail.com
- 4Department of Life Science, College of Medicine, Rheumatism Research Center, Laboratory of Immune Network, The Catholic University of Korea, Seoul, Korea.
- 5Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea.
- 6Department of Nursing Education & Administration, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Uijeongbu, Korea.
- 7Biomedical Research Coordinator, SDM College of Medical Sciences & Hospital, Sattur, Dharwad, India.
- KMID: 2360860
- DOI: http://doi.org/10.1007/s13770-016-9125-y
Abstract
- Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success. We compared data from 7 patients who underwent total knee arthroplasty and 46 patients who underwent autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) for osteoarthritis of grade IV of the Kellgren-Lawrence classification and grade IV of modified Outerbridge classification from 50 to 65 years of age. Clinical evaluation of the 2 groups showed significant improvement in the mean telephone Knee Society Scoring system (tKSS)-A (pain) and tKSS-B (function) scores throughout the postoperative follow-up period. There was no difference in the patients' satisfaction between the 2 groups. MCIC is a treatment option at least for delaying disease progression of osteoarthritis of the knee.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Bony Union of Osteochondral Lesion of the Talus after Bone Marrow Aspirate Concentrate and Matrix-Induced Chondrogenesis: A Case Report
- Cartilage Repair Using Mesenchymal Stem Cells
- Operative Treatment for Osteochondral Lesions of the Talus: Bone Marrow Aspirate Concentrate and Matrix-induced Chondrogenesis
- Current perspectives in stem cell therapies for osteoarthritis of the knee
- Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients
