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Effects of Androgen Receptor Overexpression on Chondrogenic Ability of Rabbit Articular Chondrocytes

Hui L, Shoumei X, Zhoujing Z, Kuang G, Duohong Z, Jiacai H, Yong Z

BACKGROUND: The role of sex hormones and their receptors has drawn much attention in the process of cartilage regeneration. This study aimed to investigate the effect of androgen receptor (AR)...
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Does periosteum promote chondrogenesis? A comparison of free periosteal and perichondrial grafts in the regeneration of ear cartilage

Yoo H, Yoon T, Bae HS, Kang MS, Kim BJ

Background: Elastic ear cartilage is a good source of tissue for support or augmentation in plastic and reconstructive surgery. However, the amount of ear cartilage is limited and excessive use...
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Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review

Volleman T, Schol J, Morita K, Sakai D, Watanabe M

Low back pain remains a highly prevalent pathology engendering a tremendous socioeconomic burden. Low back pain is generally associated with intervertebral disc (IVD) degeneration, a process involving the deterioration of...
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Applications of Computer Modeling and Simulation in Cartilage Tissue Engineering

Pearce D, Fischer S, Huda F, Vahdati A

Background: Advances in cartilage tissue engineering have demonstrated noteworthy potential for developing cartilage for implantation onto sites impacted by joint degeneration and injury. To supplement resource-intensive in vivo and in...
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Overcoming Current Dilemma in Cartilage Regeneration: Will Direct Conversion Provide a Breakthrough?

Im Gi, Kim TK

Direct reprogramming/direct conversion/transdifferentiation is a process that induces conversion between completely different matured (differentiated) cells in higher organisms. Unlike the process of reprogramming of differentiated cells into induced pluripotent stem...
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The Interaction between Joint Inflammation and Cartilage Repair

van der Kraan PM

BACKGROUND: Articular cartilage lesions occur frequently but unfortunately damaged cartilage has a very limited intrinsic repair capacity. Therefore, there is a high need to develop technology that makes cartilage repair...
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Current Stem Cell Therapy for Osteoarthritis

Nam Y, Rim YA, Ju JH

Osteoarthritis is a musculoskeletal disease representative of an aging society. As medical conditions are usually complicated in an aging population, osteoarthritis becomes more frequently encountered in the physician's office. There...
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TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation

Pfeifer CG, Karl A, Kerschbaum M, Berner A, Lang S, Schupfner , Koch M, Angele P, Nerlich M, Mueller MB

BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage...
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In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin

Kim TH, Yun YP, Shim KS, Kim HJ, Kim SE, Park K, Song HR

The aim of this study was to prepare inclusion nanocomplexes of hyaluronic acid-β-cyclodextrin and simvastatin (HA-β-CD/SIM) and evaluate in vitro anti-inflammation effects on lipopolysaccharide (LPS)-activated synoviocytes and chondrogenic differentiation effects...
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Chondrogenic Potential of Dedifferentiated Rat Chondrocytes Reevaluated in Two- and Three-Dimensional Culture Conditions

Jin GZ, Kim HW

For the cartilage repair, the cell sources currently adopted are primarily chondrocytes or mesenchymal stem cells (MSCs). Due to the fact that chondrocytes dedifferentiate during 2-dimensional (2D) expansion, MSCs are...
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Differentiation potential of canine mesenchymal stem cells on hydrogel scaffold-based three-dimensional environment

Gu NY, Park MJ, Lee J, Byeon JS, Jeong DU, Cho IS, Cha SH

Mesenchymal stem cells (MSCs) are useful candidates for tissue engineering and cell therapy. Physiological cell environment not only connects cells to each other, but also connects cells to the extracellular...
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Effects of Trichostatin A on the Chondrogenesis from Human Mesenchymal Stem Cells

Lee J, Im GI

Histone deacetylase inhibitors (HDACi) are a class of compounds that suppress the function of histone deacetylases (HDACs). This study was performed to examine the effects of Trichostatin A (TSA), a...
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Disc-Type Hyaline Cartilage Reconstruction Using 3D-Cell Sheet Culture of Human Bone Marrow Stromal Cells and Human Costal Chondrocytes and Maintenance of Its Shape and Phenotype after Transplantation

Jang J, Lee J, Lee E, Lee E, Son Y

In this study, we developed the disc-type bio-cartilage reconstruction strategies for transplantable hyaline cartilage for reconstructive surgery using 3D-cell sheet culture of human bone marrow stromal cells and human costal...
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Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways

Yang M, Li L, Heo SM, Soh Y

Endochondral bone formation is the process by which mesenchymal cells condense into chondrocytes, which are ultimately responsible for new bone formation. The processes of chondrogenic differentiation and hypertrophy are critical...
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Autologous Bone Marrow Mesenchymal Cell Induced Chondrogenesis for the Treatment of Osteoarthritis of Knee

Huh SW, Shetty AA, Kim JM, Cho ML, Kim SA, Yang S, Kim YJ, Javaregowda PK, Choi NY, Kang J, Kim SJ

Healthy and high quality of life has become the main issue with increasing human life span. Many biological treatments for osteoarthritis of the knee have been tried with limited success....
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Derivation and Differentiation of Bone Marrow Mesenchymal Stem Cells from Osteoarthritis Patients

Gari M, Alsehli H, Gari A, Abbas M, Alkaff M, Abuzinadah M, Al-Sayes F, Gari M, Dallol A, Abuzenadah AM, Gauthaman

Osteoarthritis (OA) of the knee is a degenerative joint disease caused by the progressive reduction of the articular cartilage surface that leads to reduced joint function. Cartilage degeneration occurs through...
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In Vivo Cartilage Formation Using Human Bone Marrow-Derived Mesenchymal Stem Cells Mixed with Fibrin Glue

Park KW, Choi WJ, Lee KM, Yoon DS, Kim SH, Lee JW

PURPOSE: To investigate the feasibility of in vivo cartilage formation by direct injection the chondrogenic undifferentiated human bone marrow-derived mesenchymal stem cells (hBMSCs) mixed with fibrin glue including TGF-beta3. MATERIALS AND...
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MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes

Zhang Y, Jia J, Yang S, Liu X, Ye S, Tian H

Osteoarthritis is a common cause of functional deterioration in older adults and is an immense burden on the aging population. Altered chondrogenesis is the most important pathophysiological process involved in...
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Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way

Kim M, Song K, Jin EJ, Sonn J

  • KMID: 1389731
  • Exp Mol Med.
  • 2012 Sep;44(9):521-528.
Actin cytoskeleton has been known to control and/or be associated with chondrogenesis. Staurosporine and cytochalasin D modulate actin cytoskeleton and affect chondrogenesis. However, the underlying mechanisms for actin dynamics regulation...
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Stimulation of Chondrogenic Differentiation of Mesenchymal Stem Cells

Yu DA, Han J, Kim BS

  • KMID: 1426153
  • Int J Stem Cells.
  • 2012 May;5(1):16-22.
The methods for cartilage repair have been studied so far, yet many of them seem to have limitations due to the low regenerative capacity of articular cartilage. Mesenchymal stem cell...
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