J Clin Neurol.
2016 Apr;12(2):172-180. 10.3988/jcn.2016.12.2.172.
Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to α-Synuclein Oligomer
- Affiliations
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- 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
- 2Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. ttyyzw@163.com
- 3Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
- 4Department of Physiology, Capital Medical University, Beijing, China.
- 5Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing, China.
- 6Department of Neurobiology, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China.
- 7Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
- 8China National Clinical Research Center for Neurological Diseases, Beijing, China.
- 9Beijing Key Laboratory on Parkinson's Disease, Beijing, China.
- KMID: 2354137
- DOI: http://doi.org/10.3988/jcn.2016.12.2.172
Abstract
- BACKGROUND AND PURPOSE
The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson's disease (PD) patients who experience fatigue.
METHODS
PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins-α-synuclein oligomer, β-amyloid (Aβ)(1-42), and tau-were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients.
RESULTS
The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of α-synuclein oligomer was higher and that of Aβ1-42 was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the α-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders.
CONCLUSIONS
PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased α-synuclein oligomer level in the CSF.
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