Korean J Fam Med.
2016 Sep;37(5):267-272. 10.4082/kjfm.2016.37.5.267.
The Relationship between the Blood Level of Persistent Organic Pollutants and Common Gastrointestinal Symptoms
- Affiliations
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- 1Department of Family Medicine, Kyungpook National University Hospital, Daegu, Korea.
- 2Department of Family Medicine, Kyungpook National University School of Medicine, Daegu, Korea. ychfm@knu.ac.kr
- 3Graduate School of Public Health, Kyungpook National University, Daegu, Korea.
- 4Regional Cardiocerebrovascular Center, Kyungpook National University Hospital, Daegu, Korea.
- KMID: 2352838
- DOI: http://doi.org/10.4082/kjfm.2016.37.5.267
Abstract
- BACKGROUND
Persistent organic pollutants (POPs) are toxic materials that cannot be broken down naturally and that easily accumulate in the body. Although several studies have attempted to reveal the effects of POPs on the endocrine and nervous system and on cancer, few studies focus on the relationship between low-dose POPs and public health. We attempted to find a relationship between the level of POPs and common gastrointestinal symptoms, including abdominal discomfort, diarrhea, and constipation.
METHODS
We recruited 121 subjects who visited Kyungpook National University Hospital for a health screening. Plasma concentrations were evaluated for 40 kinds of POPs including 17 types of polychlorinated biphenyls and 23 types of organochlorine pesticides. Furthermore, the Korean version of the Rome III criteria was used to identify gastrointestinal symptoms.
RESULTS
Our results showed that abdominal discomfort had an inverse relationship with several polychlorinated biphenyls. Moreover, an inverted U-shaped relationship was observed between abdominal discomfort and several other organochlorine pesticides including p,p'-dichlorodiphenyldichloroethane and p,p'-dichlorodiphenyltrichloroethane, and the effects of these pesticides on abdominal discomfort were similar to that of organochlorine pesticides on obesity and metabolic syndrome.
CONCLUSION
Our results suggest that mild and unspecified gastrointestinal symptoms with no clear cause could be related to POPs levels.
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