Ann Dermatol.  2007 Jun;19(2):60-67.

Effect of Trans-4-Aminomethylcyclohexanecarboxylic Acid on the Proliferation and Melanization in Cultured Normal Human Melanocytes

• Seo SJ
• Cho SH
• Cho WI
• Jung MS
• Ro SW
• Kim MN
• Hong CK

Abstract

BACKGROUND: Trans-4-aminomethylcyclohexanecarboxylic acid (tranexamic acid) has recently been reported to inhibit prostaglandin synthesis and hinder the pigmentation caused after UV radiation.
OBJECTIVE
we evaluated the influence of tranexamic acid on the viability, morphogenesis and melanization of cultured normal human melanocytes. METHOD: The cultured melanocytes from neonatal foreskin were exposed to UVB 20mJ/cm2, then treated with tranexamic acid [0.05microgram/ml, 0.05microgram/ml, and 0.5microgram/ml]. After 24 hours, the viability of melanocytes and the melanin concentration was measured. The number and length of the melanocytes' dendrites, and the expression level of tyrosinase, TRP-1 and TRP-2 were also evaluated.
RESULTS
The viability of the melanocytes was decreased by tranexamic acid in a dose dependent manner (p<0.05). The increased melanin synthesis by UVB irradiation was decreased by tranexamic acid in a dose dependent manner (p<0.05). Also, the increased expressions of TRP-1, TRP-2 and tyrosinase after exposure to UV were statistically decreased by tranexamic acid in a dose dependent manner (p<0.05).
CONCLUSION
tranexamic acid may prevents UVB induced pigmentation.

Keyword

Melanocytes; Tranexamic acid; UVB

MeSH Terms

Dendrites
Foreskin
Humans*
Melanins
Melanocytes*
Monophenol Monooxygenase
Morphogenesis
Pigmentation
Tranexamic Acid
Melanins
Monophenol Monooxygenase
Tranexamic Acid