- Pathogenesis of vitiligo
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Seok SH, Kim DH
- KMID: 2510936
- J Korean Med Assoc.
- 2020 Dec;63(12):725-730.
- doi: 10.5124/jkma.2020.63.12.725
Vitiligo is an autoimmune disease in which CD8+ T-cells target and destroy melanocytes, leaving areas of skin without pigment production. Nonsegmental vitiligo, the classical form of the disease, results in... -
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- The Role of MicroRNAs in Vitiligo: Regulators and Therapeutic Targets
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Li L
- KMID: 2508520
- Ann Dermatol.
- 2020 Dec;32(6):441-451.
- doi: 10.5021/ad.2020.32.6.441
Vitiligo is an acquired skin disorder clinically characterized by the progressive appearance of white maculae due to a loss of functioning epidermal melanocytes. Studies have shown that microRNAs (miRNAs) modulate... -
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- BMP4-Induced Differentiation of Human Hair Follicle Neural Crest Stem Cells into Precursor Melanocytes from Hair Follicle Bulge
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Yoon JH, Kim HJ, Kim JH, Kim TH, Seo CH, Sung YK, Kim KH
- KMID: 2506993
- Ann Dermatol.
- 2020 Oct;32(5):409-416.
- doi: 10.5021/ad.2020.32.5.409
Background: Vitiligo is a skin depigmentation disorder, for which, repigmentation treatment with combined follicular unit extraction (FUE) graft and narrowband ultraviolet B (NBUVB) is considered superior to micro-punch graft therapy.... -
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- NB-UVB Induces Melanocytic Differentiation of Human Hair Follicle Neural Crest Stem Cells
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Dong D, Chen S, Feng C, Xiong H, Xu X
- KMID: 2504860
- Ann Dermatol.
- 2020 Aug;32(4):289-297.
- doi: /10.5021/ad.2020.32.4.289
Background: Phototherapy is an important method to treatvitiligo. However, it is unclear how phototherapy affectsmelanocyte precursors and skin neural crest stem cells. Objective: To investigate the underlying mechanisms of narrow-band ultraviolet... -
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- Congenital Dermal Melanocytosis on the Foot: A Case Report and Review of the Literature
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Cho SI, Moon J, Jo G, Lee C, Mun JH
- KMID: 2439069
- Ann Dermatol.
- 2019 Apr;31(2):213-216.
- doi: 10.5021/ad.2019.31.2.213
Dermal melanocytosis is a common pigmented skin disease, characterized by an increased number of ectopic melanocytes in the dermis. Rare variants of dermal melanocytosis that do not belong to these... -
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- Adipose-Derived Stem Cell Coculturing Stimulates Integrin-Mediated Extracellular Matrix Adhesion of Melanocytes by Upregulating Growth Factors
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Kim H, Yi N, Do BR, Lee AY
- KMID: 2442010
- Biomol Ther.
- 2019 Feb;27(2):185-192.
- doi: 10.4062/biomolther.2018.203
Coculture with adipose-derived stem cells (ADSCs) can stimulate proliferation and migration of melanocytes. To enhance outcomes of skin disorders caused by melanocyte loss or death, mixed transplantation with ADSCs has... -
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- Three Streams for the Mechanism of Hair Graying
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Jo SK, Lee JY, Lee Y, Kim CD, Lee JH, Lee YH
- KMID: 2457515
- Ann Dermatol.
- 2018 Aug;30(4):397-401.
- doi: 10.5021/ad.2018.30.4.397
Hair graying is an obvious sign of human aging. Although graying has been investigated extensively, the mechanism remains unclear. Here, we reviewed previous studies on the mechanism of graying and... -
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- Designing Tyrosinase siRNAs by Multiple Prediction Algorithms and Evaluation of Their Anti-Melanogenic Effects
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Kwon OS, Kwon SJ, Kim JS, Lee G, Maeng HJ, Lee J, Hwang GS, Cha HJ, Chun KH
- KMID: 2421737
- Biomol Ther.
- 2018 May;26(3):282-289.
- doi: 10.4062/biomolther.2017.115
Melanin is a pigment produced from tyrosine in melanocytes. Although melanin has a protective role against UVB radiation-induced damage, it is also associated with the development of melanoma and darker... -
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- Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus
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Sheng P, Cheng YL, Cai CC, Guo WJ, Zhou Y, Shi G, Fan YM
- KMID: 2368119
- Ann Dermatol.
- 2016 Dec;28(6):697-703.
- doi: 10.5021/ad.2016.28.6.697
BACKGROUND: Although Becker's nevus (BN) is a relatively common disease, the systematic studies of clinicopathological and immunohistochemical results are poorly reported. OBJECTIVE: To investigate the clinicopathological features and immunohistochemical alterations of... -
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- Effect of MITF-M and MITF-A Overexpression on the Dendrtic Formation in Melanocytes
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Jo IS, Sohn KC, Kim CD, Lee YH
- KMID: 2161138
- Korean J Phys Anthropol.
- 2016 Mar;29(1):27-34.
- doi: 10.11637/kjpa.2016.29.1.27
The microphthalmia-associated transcription factor (MITF), has been described as the master regulator of the basic helix-loop-helix leucine zipper family, involves melanogenesis in melanocytes. MITF consists of at least six isoforms,... -
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- Modulation of Melanogenesis by Heme Oxygenase-1 via p53 in Normal Human Melanocytes
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Lim HS, Jin S, Yun SJ
- KMID: 2152655
- Chonnam Med J.
- 2016 Jan;52(1):45-52.
- doi: 10.4068/cmj.2016.52.1.45
As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and... -
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- Tranexamic Acid Diminishes Laser-Induced Melanogenesis
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Kim MS, Bang SH, Kim JH, Shin HJ, Choi JH, Chang SE
- KMID: 2352494
- Ann Dermatol.
- 2015 Jun;27(3):250-256.
- doi: 10.5021/ad.2015.27.3.250
BACKGROUND: The treatment of post-inflammatory hyperpigmentation (PIH) remains challenging. Tranexamic acid, a well-known anti-fibrinolytic drug, has recently demonstrated a curative effect towards melasma and ultraviolet-induced PIH in Asian countries. However,... -
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- Anti-melanogenic effects of black, green, and white tea extracts on immortalized melanocytes
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Kim YC, Choi SY, Park EY
- KMID: 2164521
- J Vet Sci.
- 2015 Jun;16(2):135-143.
- doi: 10.4142/jvs.2015.16.2.135
Tea contains polyphenols and is one of the most popular beverages consumed worldwide. Because most tyrosinase inhibitors that regulate melanogenesis are phenol/catechol derivatives, this study investigated the inhibitory effects of... -
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- Possible Existence of Melanocytes or Melanoblasts in Human Sebaceous Glands
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Jang YH, Kim SL, Lee JS, Kwon KY, Lee SJ, Kim DW, Lee WJ
- KMID: 2265587
- Ann Dermatol.
- 2014 Aug;26(4):469-473.
- doi: 10.5021/ad.2014.26.4.469
BACKGROUND: Melanocytes are present in both basal epidermis and hair follicles. Melanocyte stem cells have been found in hair follicle bulge. During embryogenesis, the outer cells of the bulge differentiate... -
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- Adipose-Derived Stem Cells Improve Efficacy of Melanocyte Transplantation in Animal Skin
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Lim WS, Kim CH, Kim JY, Do BR, Kim EJ, Lee AY
- KMID: 2170627
- Biomol Ther.
- 2014 Jul;22(4):328-333.
Vitiligo is a pigmentary disorder induced by a loss of melanocytes. In addition to replacement of pure melanocytes, cocultures of melanocytes with keratinocytes have been used to improve the repigmentation... -
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- Effect of Adenosine on Melanogenesis in B16 Cells and Zebrafish
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Kim MY, Lee HE, Im M, Lee Y, Kim CD, Lee JH, Seo YJ
- KMID: 2171657
- Ann Dermatol.
- 2014 Apr;26(2):209-213.
- doi: 10.5021/ad.2014.26.2.209
BACKGROUND: Adenosine is a nucleoside, in which an adenine molecule is attached to a ribofuranose sugar moiety. It can be released into the microenvironment by metabolically active cells, and then... -
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- Comparison of Gene Expression Profiles between Keratinocytes, Melanocytes and Fibroblasts
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Lee JS, Kim DH, Choi DK, Kim CD, Ahn GB, Yoon TY, Lee JH, Lee JY
- KMID: 2265969
- Ann Dermatol.
- 2013 Feb;25(1):36-45.
- doi: 10.5021/ad.2013.25.1.36
BACKGROUND: The skin has many important functions such as protection, preservation, temperature regulation, and vitamin D synthesis. It is composed of a variety of cell types including keratinocytes, melanocytes and... -
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- Activation of Toll-like Receptors 1, 2, 4, 5, and 7 on Human Melanocytes Modulate Pigmentation
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Jin SH, Kang HY
- KMID: 2266195
- Ann Dermatol.
- 2010 Nov;22(4):486-489.
- doi: 10.5021/ad.2010.22.4.486
Human melanocytes are not simply pigment-producing cells. It may be part of the inflammatory response, during which the pigmentary system may produce more melanin or suppress melanization. Toll-like receptors (TLRs)... -
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- What Should Be Considered in Treatment of Melasma
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Kang HY, Ortonne JP
- KMID: 2266172
- Ann Dermatol.
- 2010 Nov;22(4):373-378.
- doi: 10.5021/ad.2010.22.4.373
Melasma is a common acquired hyperpigmentary skin disorder characterized by light to dark brown macules and patches occurring in the sun-exposed areas of the face. Melasma lesional skin is characterized... -
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- Expression of Heat Shock Protein 70 in Human Skin Cells as a Photoprotective Function after UV Exposure
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Roh BH, Kim DH, Cho MK, Park YL, Whang KU
- KMID: 2156390
- Ann Dermatol.
- 2008 Dec;20(4):184-189.
- doi: 10.5021/ad.2008.20.4.184
BACKGROUND: Human skin is exposed to various environmental stresses, such as heat, cold, and ultraviolet (UV) radiation. Heat shock proteins (HSPs) induced by temperature elevations, as a physiologic response to... -
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