Korean J Otorhinolaryngol-Head Neck Surg.  2016 Sep;59(9):676-679. 10.3342/kjorl-hns.2016.59.9.676.

Histopathological Evaluation of Collagen Sheet (Permacol®) after Augmentation Rhinoplasty

• Kim JY
• Chang C
• Kim MK
• Yi JS

• KMID: 2352355
• DOI: http://doi.org/10.3342/kjorl-hns.2016.59.9.676

Abstract

In Asian rhinoplasty, allograft materials are often required due to insufficient amount of autologous sources for dorsal augmentation. Nowadays, Silicon and polytetrafluoroethylene are commonly used allograft materials although these can often lead to postoperative complications such as protrusion, migration or infection of implanted graft. Permacol® is a collagen sheet which is indicated for soft tissue reinforcement or repair of the head and face area in plastic and reconstructive surgery. Its clinical safety and stability is well established with low complication rates. However, its histopathology has rarely investigated, especially in human. Thus, we reviewed histopathology of two graft-removal cases of patients who had undergone rhinoplasty using Permacol®. In conclusion, Permacol® can lead to fibrosis of imbedded tissues with or without absorption in long-term follow-up. Although Permacol® is gradually absorbed as time passes, the implanted graft can maintain its volume by replaced fibrotic connective tissues.

Keyword

Augmentation; Collagen implant; Permacol; Rhinoplasty

MeSH Terms

Absorption
Allografts
Asian Continental Ancestry Group
Collagen*
Connective Tissue
Fibrosis
Follow-Up Studies
Head
Humans
Plastics
Polytetrafluoroethylene
Postoperative Complications
Rhinoplasty*
Silicon
Transplants
Collagen
Plastics
Polytetrafluoroethylene
Silicon