J Korean Dent Soc Anesthesiol.  2006 Dec;6(2):89-97. 10.17245/jkdsa.2006.6.2.89.

Effect of Submucosal Midazolam on Percutaneous Saturation Percentage of Oxygen (SpOâ‚‚), End-tidal Carbon Dioxide (EtCOâ‚‚) and Physiologic Response When Combined with Chloral Hydrate, Hydroxyzine and Nitrous Oxide Sedation

• Yu J
• Kim Y
• Jung S
• Baek K

• KMID: 2345141
• DOI: http://doi.org/10.17245/jkdsa.2006.6.2.89

Abstract

BACKGROUND
The aim of this study was to examine the difference of SpOâ‚‚, PR, EtCOâ‚‚, RR with submucosal injection of midazolam to oral chloral hydrate and hydroxyzine for pediatric patients
METHODS
Thirty two sedation cases were performed in this study. Patients were randomly classified into one group taking oral CH (60 mg/kg), hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.1 mg/kg) and the other group recieving oral CH (50 mg/kg), hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.2 mg/kg). For evaluating the depth of sedation, data including saturation percentage of oxygen (SpOâ‚‚), pulse rate (PR), end-tidal carbon dioxide (EtCOâ‚‚), respiratory rate (RR) and the behavior scale were checked every 2 minutes and were collected for only 40 minutes from the beginning of treatment and were analyzed using Two independent sample T-test.
RESULTS
Analysis showed no significant difference in the mean SpOâ‚‚, PR, EtCOâ‚‚, RR during sedation between two groups (P>0.05). The values of SpOâ‚‚, PR, EtCOâ‚‚ and RR for both groups remained within the normal values.
CONCLUSIONS
The results of this present study indicate that combination of oral CH, hydroxyzine, nitrous oxide gas inhalation and submucosal injection of midazolam improved the sedation quality without compromising safety.

Keyword

Conscious sedation; Submucosal midazolam; Chloral hydrate; Nitrous oxide

MeSH Terms

Carbon Dioxide*
Carbon*
Chloral Hydrate*
Conscious Sedation
Heart Rate
Humans
Hydroxyzine*
Inhalation
Midazolam*
Nitrous Oxide*
Oxygen*
Reference Values
Respiratory Rate
Carbon
Carbon Dioxide
Chloral Hydrate
Hydroxyzine
Midazolam
Nitrous Oxide
Oxygen