J Korean Dent Soc Anesthesiol.  2008 Jun;8(1):16-21. 10.17245/jkdsa.2008.8.1.16.

Sedative Effect of Sublingual Midazolam after Oral Chloral Hydrate or Hydroxyzine in Children

• Lee H
• Baek K
• Jung S

• KMID: 2345122
• DOI: http://doi.org/10.17245/jkdsa.2008.8.1.16

Abstract

Recently combining regimen of minimal doses of chloral hydrate, hydroxyzine and midazolam is good in sedation of children. Midazoalm, water soluble benzdiazepine, has rapid onset and relatively short duration of action. And midazolam has prospective amnesic effect. With these advantages midazolam is popular in conscious sedation for children. This study was to reveal the dose-dependency of behavior and physiologic effects of sublingual midazolam. Sedation records were surveyed retrospectively, of which the patients admitted from April, 2005 to July, 2007. we assigned three groups according the dose of midazolam, 0.1 mg/kg, 0.2 mg/kg and 0.3 mg/kg, respectively and the behavioral evaluation was analyzed with Houpt scale statistically. Combined sublingual midazolam increased the success rate in sedation and the vital signs were stable during sedation.

Keyword

Conscious sedation; Submucosal midazolam; Chloral hydrate; Hydroxyzine

MeSH Terms

Child*
Chloral Hydrate*
Conscious Sedation
Humans
Hydroxyzine*
Hypnotics and Sedatives*
Midazolam*
Prospective Studies
Retrospective Studies
Vital Signs
Water
Chloral Hydrate
Hydroxyzine
Hypnotics and Sedatives
Midazolam
Water