J Korean Dent Soc Anesthesiol.  2008 Dec;8(2):113-117. 10.17245/jkdsa.2008.8.2.113.

Comparison of the Use of Midazolam Only with Midazolam Combined with Fentanyl or Propofol in IV sedation

Affiliations
  • 1Department of Oral & Maxillofacial Surgery, Daegu Fatima Hospital, Korea.
  • 2Department of Oral & Maxillofacial Surgery, Dongguk University Gyongju Hospital, Korea.
  • 3Zenith Dental Clinic, Korea. drjanghs2002@yahoo.co.kr

Abstract

BACKGROUND
The purpose of this study was to compare the use of midazolam only with midazolam with fentanyl or propofol in IV sedation.
METHODS
24 cases were divided to midazolam group (M group), midazolam + fentanyl group (MF group), midazolam + propofol group (MP group) and midazolam + fentanyl + propofol group (MFP group). In M group, 2 ml midazolam was injected at first, than at 2 minutes interval 1-2 ml injected continuously depending on the level of sedation. In MP, MFP groups, propofol was injected at the speed of 15-20 ml/hr by infusion pump. In this study, the sedation level was evaluated by using OAA/S scale. In each groups, the recovery time was measured until OAA/S scale score level was 5, and pre and postoperative blood pressure change was measured. Each group's data was statistically analyzed using one-way ANOVA. If significant statistical difference were observed, Dunnet test was performed, and control group was M group.
RESULTS
Pre and postoperative blood pressure change were not represent significant statistical difference in 4 groups (P value = 0.679 [systolic], P value = 0.206 [diastolic]). But recovery time were represent significant statistical difference (M group: 35.6, MF group: 32.5, MP group: 17.9, MFP group: 19.6 [P value = 0.002]). The result of Dunnet test on recovery time showed significant statistical difference on MF, MFP group when M group was control group. In MFP group, sedation was increased by using supplemental fentanyl, and postoperative pain control was dominant.
CONCLUSION
To achieve the effect of anxiolysis, analgesia, amnesia effectively, and short recovery time, MFP group is mostly recommended.

Keyword

Conscious sedation; Midazolam; Fentanyl; Propofol

MeSH Terms

Amnesia
Analgesia
Blood Pressure
Conscious Sedation
Fentanyl*
Infusion Pumps
Midazolam*
Pain, Postoperative
Propofol*
Fentanyl
Midazolam
Propofol
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