J Korean Soc Radiol.  2016 Aug;75(2):151-156. 10.3348/jksr.2016.75.2.151.

Thoracic Air-Leakage Syndrome in Allogeneic Stem Cell Transplant Recipients as a Late Complication of Chronic Graft-versus-Host Disease: Case Reports

Affiliations
  • 1Department of Radiology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea. haneul88@hanmail.net
  • 2Division of Hematology and Oncology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.

Abstract

Air-leakage syndrome associated with graft-versus-host disease (GVHD) is a rare complication, but it is also reported as an independent predictor of a worse survival rate after stem cell transplantation. We report two cases of air-leakage syndrome associated with GVHD after allogeneic stem cell transplantation in acute leukemia patients who presented with spontaneous pneumomediastinum and subcutaneous emphysema, and finally death due to respiratory failure seven to eight months later.


MeSH Terms

Bronchiolitis Obliterans
Graft vs Host Disease*
Hematopoietic Stem Cell Transplantation
Humans
Leukemia
Mediastinal Emphysema
Respiratory Insufficiency
Stem Cell Transplantation
Stem Cells*
Subcutaneous Emphysema
Survival Rate
Transplant Recipients*
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