Korean J Med.  2008 Apr;74(4):445-450.

Air-leakage syndrome after allogeneic peripheral blood stem cell transplantation from unrelated donor

Affiliations
  • 1Catholic Hemopoietic Stem Cell Transplantation Center, St. Mary's Hospital, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. cumckim@catholic.ac.kr

Abstract

Bronchiolitis obliterans, a late, non-infectious pulmonary complication of bone marrow transplantation (BMT), is an obstructive airway disease associated with chronic graft-versus-host disease (cGVHD). We report a rare case of air-leakage syndrome including pneumothoraces, pneumomediastinum, and subcutaneous emphysema with bronchiolitis obliterans after allogeneic peripheral blood stem cell transplantation (PBSCT) from an unrelated donor. The pathogenesis of air-leakage syndrome is not fully understood, and its management has not yet been established. This patient was treated with high-concentration oxygen, tube thoracostomy, percutaneous drainage with a pigtail catheter to relieve the tension pneumomediastinum, and mechanical ventilatory support. The patient has now recovered and is being followed on an outpatient basis.

Keyword

Air-leakage syndrome; Bronchiolitis obliterans; Peripheral blood stem cell transplantation

MeSH Terms

Bone Marrow Transplantation
Bronchiolitis Obliterans
Catheters
Drainage
Graft vs Host Disease
Humans
Mediastinal Emphysema
Outpatients
Oxygen
Peripheral Blood Stem Cell Transplantation
Subcutaneous Emphysema
Thoracostomy
Unrelated Donors
Oxygen
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