J Korean Neuropsychiatr Assoc.
2007 Nov;46(6):573-578.
Association between EGF A61G Polymorphism and Bipolar Disorder in Korean Population
- Affiliations
-
- 1Department of Neuropsychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea. kys@snu.ac.kr
- 2Research Division of Human Life Science, Seoul National University College of Medicine, Seoul, Korea.
- 3Department of Psychiatry, Eulji University College of Medicine, Eulji General Hospital, Seoul, Korea.
- 4Department of Psychiatry and Behavioral Neuroscience and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVES
Epidermal growth factor (EGF) is a neurotrophic factor which regulates the intracellular signaling molecules. These molecules are also affected by mood stabilizers such as lithium and valproate. In addition, epidermal growth factor enhances neuronal survival, maturation and differentiation especially in midbrain dopaminergic neurons of which dysfunction may play a role in pathophysiology of bipolar disorders. Bipolar disorder has some genetic commonalities with schizophrenia, and several association studies of EGF have been done with schizophrenia. In this study, we tried to investigate the genetic association between EGF A61G polymorphism and bipolar disorder.
METHODS
Total of 189 patients and 347 normal control were included. All patients satisfied the diagnostic criteria of DSM-IV for bipolar disorder type I (BPDI, N=146) and bipolar disorder type II (BPDII, N=43). Genomic DNA was extracted from the peripheral blood, and genotyping was performed by TaqManTM method. Genotype and allele frequency of EGF A61G polymorphism between the patients and the control were compared by contingency chi-square test or the Fisher's exact test.
RESULTS
No association was found between EGF A61G polymorphism and susceptibility of BPDI, BPDII and bipolar disorder (all patients). Female patients with BPDII showed overexpression of AG genotype compared to that of control group (p=0.03). However, this association was not significant after correction of multiple testing.
CONCLUSION
In conclusion, EGF A61G polymorphism has no association with susceptibility of bipolar disorder. However, the disease modifying role of EGF gene polymorphism for bipolar disorder remains to be elucidated in respect to factors such as gender difference or diagnostic subtype.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Association between 5-HT2A Receptor Gene Promoter -1438A/G Polymorphism and Bipolar Disorder in a Korean Population
- No Association between DRD2 polymorphism Ser311/Cys311 and Bipolar Disorder in Korean Population
- Association of CACNA1C Variants with Bipolar Disorder in the Korean Population
- The Tryptophan Hydroxylase A218C Polymorphism in Patients with Bipolar Disorder
- Association Study of Single-Nucleotide Polymorphism in Lymphotoxin Alpha Gene and Bipolar I Disorder
