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Adverse Skin Reactions with Antiepileptic Drugs Using Korea Adverse Event Reporting System Database, 2008–2017

Kim HK, Kim DY, Bae EK, Kim DW

BACKGROUND: Severe and life-threatening drug eruptions include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). One class of medications that has been...
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Antiphospholipid and Antinuclear Antibodies in Children with Idiopathic Epilepsy: A 2-Year Prospective Study

Attilakos , Fotis L, Dinopoulos A, Alexopoulos H, Theofilopoulou AV, Tzioufas A, Mastroyianni S, Karalexi M, Garoufi A

BACKGROUND AND PURPOSE: The high prevalence of antiphospholipid antibodies (aPL) and antinuclear antibodies (ANA) in patients with epilepsy may be associated with either the disease itself or the antiepileptic treatment....
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Severe Cutaneous Adverse Reactions to Antiepileptic Drugs: A Nationwide Registry-Based Study in Korea

Park CS, Kang DY, Kang MG, Kim S, Ye YM, Kim SH, Park HK, Park JW, Nam YH, Yang MS, Jee YK, Jung JW, Kim SH, Kim CW, Kim MY, Kim JH, Lee J, Lee JG, Kim SH, La HO, Kim MH, Park SJ, Koh YI, Lee SM, Kwon YE, Jin HJ, Kim HK, Kang HR, Choi JH, Korean Registry of Severe Cutaneous Adverse Reactions Consortium

PURPOSE: Severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) to antiepileptic drug (AED), are rare, but...
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HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice

Kim T, Song S, Park Y, Kang S, Seo H

Parkinson’s disease (PD) is one of the late-onset neurodegenerative movement disorder. Major pathological markers of PD include progressive loss of dopaminergic neurons, Lewy body formation, genetic mutations, and environmental factors....
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Antiepileptic drug-induced severe cutaneous adverse reactions and HLA alleles: A report of five cases with lymphocyte activation test

Kim EY, Kim MY, Park CS, Choi JH, Ghim JL, Kim HS, Shin JG

Antiepileptic drugs (AEDs) can induce severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. We...
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Dexmedetomidine and propofol sedation requirements in an autistic rat model

Elmorsy SA, Soliman GF, Rashed LA, Elgendy H

BACKGROUND: Autism is a challenging neurodevelopmental disorder. Previous clinical observations have suggested altered sedation requirements for children with autism. Our study aimed to test this observation experimentally in an animal...
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Korean Medication Algorithm for Bipolar Disorder 2018: Comparisons with Other Treatment Guidelines

Jeong JH, Bahk WM, Woo YS, Lee JG, Kim MD, Sohn I, Shim SH, Jon DI, Seo JS, Kim W, Song HR, Min KJ, Yoon BH

The objective of this study was to compare recommendations of the Korean Medication Algorithm Project for Bipolar Disorder 2018 (KMAP-BP 2018) with other recently published guidelines for treating bipolar disorder....
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Valproate Induced Hair Loss and Curly Hair in Bipolar Disorder

Uygur OF, Uygur H

No abstract available.
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Prosopometamorphopsia and Visual Field Defect Improved by Valproic acid in a CADASIL Patient

Hwangbo J, Cho JW, Jung SH, Shin JH, Jung NY

Persistent aura without infarction is defined as an aura persisting for 1 week or more without evidence of infarction on neuroimaging. It is difficult to differentiate persistent visual aura without...
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Valproate Is Contraindicated in POLG1 Mutations

Finsterer

No abstract available.
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Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice

Kee HJ, Ryu Y, Seok YM, Choi SY, Sun S, Kim GR, Jeong MH

BACKGROUND: The dysregulation of histone deacetylase (HDAC) protein expression or its enzyme activity is implicated in a variety of diseases. Cardiac HDAC6 and HDAC8 enzyme activity induced by deoxycorticosterone acetate...
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Korean Medication Algorithm for Bipolar Disorder 2018 : Rapid Cycling

Jeong JH, Bahk WM, Yoon BH, Jon DI, Seo JS, Kim W, Lee JG, Woo YS, Kim MD, Sohn I, Shim SH, Song HR, Min KJ

OBJECTIVES: The objective of this study was to revise the Korean Medication Algorithm Project for Bipolar Disorder 2014 for rapid cycling. METHODS: The questionnaires, which were intended to survey experts for...
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Effect of Valproic Acid on Nitric Oxide and Nitric Oxide Synthase in Trabecular Meshwork Cell

Son MS, Park CH, Kim JW

PURPOSE: To investigate the effects of valproic acid on the production of nitric oxide (NO) and expression of endothelial nitric oxide synthase (eNOS) in cultured human trabecular meshwork cells (HTMC). METHODS:...
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Early Postnatal Valproic Acid Exposure Increase the Protein Level of Astrocyte Markers in Frontal Cortex of Rat

Mony TJ, Lee JW, Kim SS, Chun W, Lee HJ

OBJECTIVE: In our previous study, it has been reported that valproic acid (VPA) effects gliogenesis and increases the number of glial precursor cells during the early postnatal period. However there...
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Effectiveness of Combining Behavioral Treatment With Valproic Acid for Dysphagia Caused by Palatal Myoclonus in Patients With Stroke: Two Case Reports

Kim BR, Lee Y, Kim SJ, Kim H, Lee JW, Lee S, Lee J

Palatal myoclonus (PM) is a rare disease that may induce dysphagia. Since dysphagia related to PM is unique and is characterized by myoclonic movements of the involved muscles, specific treatments...
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Transient Abnormalities on Magnetic Resonance Imaging after Absence Seizures

Yoo HW, Yoon L, Kim HY, Kwak MJ, Park KH, Bae MH, Lee Y, Nam SO, Kim YM

Magnetic resonance imaging (MRI) is recommended for patients with epileptic seizures to rule out an underlying focal lesion. However, abnormalities in idiopathic generalized epilepsy, including childhood absence epilepsy, cannot usually...
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Effects of Anticonvulsant Monotherapy on Bone Mineral Density in Children

Shin C, Lee NY, Han JY, Yoo IH, Eom TH, Bin JH, Kim YH, Chung SY, Lee IG

PURPOSE: The use of anticonvulsants can cause side effects such as reduction of bone mineral density, requiring attention in growing children. The aim of our study is to investigate the...
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Antiepileptic and anti-neuroinflammatory effects of red ginseng in an intrahippocampal kainic acid model of temporal lobe epilepsy demonstrated by electroencephalography

Kim JY, Kim JH, Lee HJ, Kim SH, Jung YJ, Lee HY, Kim HJ, Kim SY

BACKGROUND: Chronic inflammation can lower the seizure threshold and have influence on epileptogenesis. The components of red ginseng (RG) have anti-inflammatory effects. The abundance of peripherally derived immune cells in...
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Korean Medication Algorithm for Bipolar Disorder 2018 : Medical Comorbidity

Song HR, Bahk WM, Yoon BH, Jon DI, Seo JS, Kim W, Lee JG, Woo YS, Jeong JH, Kim MD, Sohn I, Shim SH, Min KJ

OBJECTIVES: The fourth revision of Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) was performed in 2018, to provide newer guidelines for clinicians. In this section, we examined expert opinions...
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Korean Medication Algorithm for Bipolar Disorder 2018 : Children and Adolescents

Shim SH, Bahk WM, Yoon BH, Jon DI, Seo JS, Kim W, Lee JG, Woo YS, Jeong JH, Kim MD, Sohn I, Song HR, Min KJ

OBJECTIVES: The objective of this study was to revise the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) 2014: Children and Adolescents. METHODS: We performed the survey, using a questionnaire comprising...
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