J Korean Epilepsy Soc.  2007 Jun;11(1):64-66.

The Recurrence of Seizure due to Decreased Valproic Acid Level after Administration of Carbapenem

  • 1Department of Neurology, College of Medicine, Pochon CHA University, Seongnam, Korea. okjun77@cha.ac.kr, okjun77@hanmail.net


Valproic acid (VPA) is one of the most commonly used antiepileptic drug, but has many drug-drug interactions. A 58-year-old male under the vegetative state has been well controlled with valproic acid (VPA) monotherapy without seizure attacks during the last 6 months. Pneumonia developed and panipenem-betamipron (PAPM-BP) for acinetobacter baumannii was administered. Seizure attacks recurred after 12 days of initiating PAPM-BP. During the maintenance period of PAPM-BP, serum level of VPA was decreased. After the cessation of PAPM-BP, serum level of VPA increased to the previous level without further seizure attacks. PAPM-BP should be cautiously used together with VPA because of possible drug-drug interaction.


Valproic acid; Panipenem-betamipron; Seizure
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