Korean J Dermatol.
2005 Aug;43(8):1105-1109.
Two Cases of Stevens-Johnson Syndrome Related to Concomitant Use of Lamotrigine and Valproic Acid
- Affiliations
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- 1Department of Dermatology, College of Medicine, Cheju National University, Jeju, Korea. rulidroxim@hanmail.net
- 2Department of General surgery, College of Medicine, Cheju National University, Jeju, Korea.
Abstract
- Lamotrigine (LTG) is a relatively safe and new antiepiletic drug which is effective for bipolar depression and partial or generalized seizures. However, administration of LTG in combination with valproic acid may lead to fatal Stevens-Johnson syndrome (SJS)or Toxic Epidermal Necrolysis (TEN). Valproic acid may increase serum LTG levels or induce accumulation of a toxic intermediate metabolite by doubling the plasma half-life of LTG, due to competition with hepatic glucuronidation of LTG. Although there are several published case reports of LTG-induced SJS or TEN in Western countries, we have failed to find any corresponding cases in the Korean literature until now. Herein, we present two cases of SJS associated with concomitant use of LTG and valproic acid.
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