The Effect of Valproic Acid on Ovary of Pubertal Child

Moon, Eun Kyoung; Lim, Hae Kyung; Yoo, Jae Hong; Lee, Keon Su

Abstract

PURPOSE: Valproic acid is effective and safe in adults and children for the treatment of a variety of seizure types. But, according to the recent reports, this drug induce hyperandrogenism, obesity, and polycystic ovaries, particularly when the medication is started before the age of 20. This research was designed to study the effect of valproic acid on ovary of pubertal child.
METHODS
The sample group consisted of 23 girls who were diagnosed to epilepsy by our department of pediatrics, and were taking valproic acid from January 2000 to July 2000. They were evaluated reproductive endocrine function with the serum sex hormones and ultrasonographic study of ovary.
RESULTS
1) The mean serum sex hormones concentration of prepubertal, pubertal, and postpubertal girls taking valproic acid were belong to the normal range of reference values of textbook of Nelson and Park's report. 2) The obesity were seen in two of the 23 girls taking valproic acid. 3) The rate of polycystic ovaries in normal girls with regular menstruation has been reported in 9%, but, in our report, polycystic ovaries were seen in five of the 20 girls taking valproic acid(25%).
CONCLUSION
Ultrasonographic study of ovaries is required for the girls taking valproic acid. If the problems from the polycystic ovary are developed on patients taking valproic acid, the substitution of other anticonvulsant drug for valproic acid may be required. However, further study was needed to clarify whether this ovarian morphologic changes were elicited by valproic acid or not.