Ann Dermatol.  2015 Dec;27(6):765-766. 10.5021/ad.2015.27.6.765.

Erythema Nodosum Associated with Valproate

• Woo YR
• Koo DW
• Jung KE
• Lee JS

• KMID: 2157458
• DOI: http://doi.org/10.5021/ad.2015.27.6.765

Abstract

No abstract available.

MeSH Terms

Erythema Nodosum*
Erythema*
Valproic Acid*
Valproic Acid

Figure

• 

  Fig. 1 (A, B) Tender, bilateral, multiple, erythematous to violaceous subcutaneous indurated nodules and plaques on the anterior aspect of the lower extremities. (C) Inflammatory infiltrate is mainly present in the thickened septa of the subcutaneous layer (H&E, ×40). (D) Higher magnification showed lymphocytes arranged interstitially between thickened septa and extended to the periseptal areas in the subcutaneous layer (×100).

Reference

1. Requena L, Sánchez Yus E. Erythema nodosum. Semin Cutan Med Surg. 2007; 26:114–125.

2. Rosenberg G. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees. Cell Mol Life Sci. 2007; 64:2090–2103.

3. Gerstner T, Büsing D, Bell N, Longin E, Kasper JM, Klostermann W, et al. Valproic acid-induced pancreatitis: 16 new cases and a review of the literature. J Gastroenterol. 2007; 42:39–48.

4. Hebert AA, Ralston JP. Cutaneous reactions to anticonvulsant medications. J Clin Psychiatry. 2001; 62:14. 22–26.

5. Eyer F, Felgenhauer N, Gempel K, Steimer W, Gerbitz KD, Zilker T. Acute valproate poisoning: pharmacokinetics, alteration in fatty acid metabolism, and changes during therapy. J Clin Psychopharmacol. 2005; 25:376–380.