Psychiatry Investig.  2016 Jul;13(4):453-457. 10.4306/pi.2016.13.4.453.

Association of CACNA1C Variants with Bipolar Disorder in the Korean Population

• Kim S
• Cho CH
• Geum D
• Lee HJ

• KMID: 2344745
• DOI: http://doi.org/10.4306/pi.2016.13.4.453

Abstract

OBJECTIVE
Previous studies have suggested an association between CACNA1C and susceptibility of bipolar disorder. In this study, we examined the association of CACNA1C variants with bipolar disorder in the Korean population.
METHODS
We selected 2 CACNA1C single nucleotide polymorphisms (SNPs), namely, rs723672 and rs1051375, based on their functions and minor allele frequencies described in previous studies. Genotypes of these 2 SNPs were analyzed by extracting DNA from blood samples collected from 287 patients with bipolar disorder and 340 healthy controls.
RESULTS
Genotype frequencies of both rs723672 and rs1051375 SNPs were significantly different in patients and controls (p=0.0462 and 1.732E-14, respectively). Dominant, recessive, and allele models showed significant differences between patients and controls with respect to the rs1051375 SNP (p=1.72E-11, 4.17E-10, 4.95E-16, respectively).
CONCLUSION
Our results suggested that CACNA1C SNPs rs723672 and rs1051375 were associated with bipolar disorder in the Korean population. In addition, our results highlighted the importance of CACNA1C in determining susceptibility to bipolar disorder.

Keyword

Bipolar disorder; CACNA1C; Polymorphism

MeSH Terms

Alleles
Bipolar Disorder*
DNA
Gene Frequency
Genotype
Humans
Polymorphism, Single Nucleotide
DNA