J Korean Neuropsychiatr Assoc.
2005 Jan;44(1):32-40.
A Family-based and Case-control Association Study of the Dopamine D5 Receptor Gene Polymorphism in Attention Deficit Hyperactivity Disorder
- Affiliations
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- 1Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea.
- 2Devision of Child & Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Korea.
- 3Department of Psychiatry, College of Medicine, Dankook University, Cheonan, Korea.
- 4Department of Psychiatry, College of Medicine, Gyeongsang National University, Jinju, Korea.
- 5Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Korea.
- 6Department of Psychiatry, College of Medicine, Chonbuk National University, Jeonju, Korea. ptaewon@chonbuk.ac.kr
- 7Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 8BK21 Research Division for Human Life Science, Seoul National University, Seoul, Korea.
Abstract
OBJECTIVES
Recent genetic studies have suggested a preferential transmission of the Dopamine D5 receptor gene (DRD5) 148bp marker allele. The aim of this study is to test the association between DRD5 and ADHD.
METHODS
106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk test (HHRR). And also the ADHD children were compared with 212 age and gender matched normal controls.
RESULTS
We found the evidence for an association of short alleles of DRD5 dinucleotide repeat polymorphism in both case control and family based studyies. Additionally, we observed some evidence for biased transmission of allele 152 bp and 144 bp.
CONCLUSION
Our results lend credence to the notion that the relationship between ADHD and DRD5 is complex. The number of cases and informative transmissions in our study were small, therefore it would be premature to make any conclusions concerning the role of DRD5 in ADHD. Further work is needed to support these findings.
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