J Korean Neuropsychiatr Assoc.  2003 Mar;42(2):202-207.

Dopamine D2 Receptor Gene Polymorphism in Cigarette Smoking

Affiliations
  • 1Department of Neuropsychiatry, Korea University College of Medicine, Seoul, Song's, Korea.
  • 2Neuropsychiatric Clinic, Masan, Korea.
  • 3Department of Psychiatry, Eumsung Mental Hospital, Eumseong, Korea.

Abstract


OBJECTIVE
This study was to examine the effects of DRD2 TaqI A polymorphism on the smoking in Koreans. Also this study examined molecular heterosis and gender difference in the genetic effect of cigarette smoking.
METHODS
DRD2 TaqI A RFLP genotyping was carried out with DNA extracted from blood samples of 187 healthy individuals including 94 smokers and 93 non-smokers,
RESULTS
Among the total subjects, the smokers were not significantly different from the non-smokers in respect to the frequency and prevalence of A1 allele, the genotype distribution, or the frequency of heterozygotes. Separating the subjects by gender, however, in male subjects smokers showed a significantly higher frequency (p=0.049) and prevalence of A1 allele (p=0.016) than non-smokers. Also, genotype distribution (p=0.055) and frequency of heterozygotes (p=0.058) of smokers showed some different distributions, but there were no significant statistical difference. In contrast, female subjects showed significant difference between smokers and non-smokers in the comparison of frequency of heterozygotes (p=0.018), but not in the comparison of the frequency (p=0.582) and prevalence (p=0.082) of A1 allele and genotype distribution (p=0.060).
CONCLUSION
No significant difference between smokers and non-smokers in the genotype distributions of the total sample could be explained by the reciprocal effects of gender difference in the genetic effect of DRD2 A1 allele of the smoking. Our findings support gender difference and molecular heterosis at the DRD2 gene effects of smoking.

Keyword

Heterosis; Smoking; Dopamine D2 receptor; Polymorphism; Gender difference

MeSH Terms

Alleles
DNA
Dopamine*
Female
Genotype
Heterozygote
Humans
Hybrid Vigor
Male
Polymorphism, Restriction Fragment Length
Prevalence
Receptors, Dopamine D2*
Smoke
Smoking*
Tobacco Products*
DNA
Dopamine
Receptors, Dopamine D2
Smoke
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