J Korean Neuropsychiatr Assoc.
1999 Sep;38(5):1071-1076.
Effect of Sertraline on the Regulation of Serotonin Transporter mRNA Levels in Rat Brain
- Affiliations
-
- 1Department of Psychiatry, Ulsan University College of Medicine, Asan Medical Center, Seoul, Korea.
- 2Department of Biochemistry, Ulsan University, School of Medicine, Ulsan, Korea.
Abstract
- The knowledge of gene regulation of serotonin transporter mRNA may provide clues to understanding how antidepressants affect their therapeutic actions. Recently, the effects of antidepressants on the serotonin transporter have been investigated but yielded controversial results. To study this further, we performed in situ hybridization for serotonin transporter mRNA in rats(treatment group, n=5)receiving long term(14 days)treatment with a selective serotonin reuptake inhibiting antidepressant, sertraline(10mg/kg, i.p) Following sertraline treatment, a significant(p<0.05)ncrease in hybridization of serotonin transporter mRNA was observed compared to that observed in vehicle-treated rats(control group, n=5) This result may be interpreted as a compensatory mechanism to reduce synaptic levels of serotonin which were increased by long term sertraline treatment.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Comparison between Dothiepin-Sertraline Combination and Dothiepin Alone Therapy in the Treatment of Depressive Disorder
- Sertraline Treatment in Premature Ejaculation: A Double Blind, Randomized, Placebo-Controlled Study
- Wide Spectrum of Inhibitory Effects of Sertraline on Cardiac Ion Channels
- Serum Prolactin Levels in Patients with Major Depressive Disorder Receiving Selective Serotonin-Reuptake Inhibitor Monotherapy for 3 Months: A Prospective Study
- Effect of serotonin uptake inhibitors on serotonin metabolism in the hypothalamus of freely moving rats
