J Korean Ophthalmol Soc.  1999 Feb;40(2):299-311.

The Effect of Topical Mitomycin-C on the Patency of Internal Nasal Ostium of the Experimental Antrorhinostomy in Rabbits

• Rhee K
• Lee TS

Abstract

The purpose of this study is to evaluate the effect of topical mitomycin C as an adjuvant therapeutic agent on prevention of internal nasal ostium obstruction in experimental rabbit dacryocystorhinostomy model. Forty-two rabbits received an osteotomy between maxillary antrum and nasal cavity. Topical mitomycin C solution had been instilled postoperatively for five days. The diameter of remaining ostium was measured and histopathologic study was performed. At 8 postoperative weeks, the ostial diameter of mitomycin C treated group was larger than that of control group. Nasal mucosa of control group showed active fibroblast and abundunt collagen fibers. But nasal mucosa of MMC group showed degenerated fibroblast and scanty collagen fibers. In conclusion, these results suggest that topical MMC eyedrop may be used as an effective adjuvant in preventing fibrous obstruction of internal nasal ostium in dacryocystorhinostomy.

Keyword

Collagen fibers; Experimental dacryocystorhinostomy model; Fibroblast; Topical mitomycin C; Internal nasal ostium

MeSH Terms

Collagen
Dacryocystorhinostomy
Fibroblasts
Maxillary Sinus
Mitomycin*
Nasal Cavity
Nasal Mucosa
Osteotomy
Rabbits*
Collagen
Mitomycin