Korean J Ophthalmol.  1995 Jun;9(1):51-58. 10.3341/kjo.1995.9.1.51.

Effects of mitomycin C on delayed adjustment in experimental strabismus surgery

• Oh SO
• Chang BL
• Lee J

• KMID: 1735137
• DOI: http://doi.org/10.3341/kjo.1995.9.1.51

Abstract

In adjustable strabismus surgery, a satisfactory final result would be achieved with delayed adjustment. However, the postoperative adhesions following strabismus surgery make delayed adjustment impossible. We evaluated the efficacy of mitomycin C in reducing the severity of postoperative adhesions following strabismus surgery and in delaying the time adjustment after surgery. Experimental rabbits underwent a hang-back recession procedure in the superior rectus muscle. A topical application of mitomycin C was made between the conjunctiva and the sclera for 5 minutes during the operation. We then studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The topical application of 0.1 mg/ml mitomycin C between the conjunctiva and sclera allowed for a 2-week delayed adjustment after surgery, and 0.2 mg/ml mitomycin C prevented the adhesions between these tissues and the muscle 5 weeks after surgery. These results suggest that topical mitomycin C may enhance the success rate of strabismus surgery with delayed adjustment and reduce postoperative adhesions.

Keyword

adjustable strabismus surgery; delayed adjustment; postoperative adhesions; mtomycin C

MeSH Terms

Administration, Topical
Animals
Chemotherapy, Adjuvant
Conjunctiva/drug effects
Mitomycin/administration & dosage/*pharmacology
Oculomotor Muscles/drug effects/pathology/*surgery
Ophthalmic Solutions
Postoperative Complications/prevention & control
Rabbits
Sclera/drug effects
Strabismus/drug therapy/pathology/*surgery
Suture Techniques
Tissue Adhesions/prevention & control
Mitomycin
Ophthalmic Solutions