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Anti-Inflammatory Effect for Atherosclerosis Progression by Sodium-Glucose Cotransporter 2 (SGLT-2) Inhibitor in a Normoglycemic Rabbit Model

Lee SG, Lee SJ, Lee JJ, Kim JS, Lee OH, Kim CK, Kim D, Lee YH, Oh J, Park S, Jeon OH, Hong SJ, Ahn CM, Kim BK, Ko YG, Choi D, Hong MK, Jang Y

BACKGROUND AND OBJECTIVES: We sought to investigate an anti-atherosclerotic and anti-inflammatory effect of sodium-glucose cotransporter-2 (SGLT-2) inhibitors in normoglycemic atherosclerotic rabbit model. METHODS: Male New Zealand white rabbits (n=26) were fed...
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Distinctive bone regeneration of calvarial defects using biphasic calcium phosphate supplemented ultraviolet-crosslinked collagen membrane

Hong I, Khalid AW, Pae HC, Cha JK, Lee JS, Paik JW, Jung UW, Choi SH

PURPOSE: To overcome several drawbacks of chemically-crosslinked collagen membranes, modification processes such as ultraviolet (UV) crosslinking and the addition of biphasic calcium phosphate (BCP) to collagen membranes have been introduced....
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Assessment of stem cell viability in the initial healing period in rabbits with a cranial bone defect according to the type and form of scaffold

Kang SH, Park JB, Kim I, Lee W, Kim H

PURPOSE: Increased bone regeneration has been achieved through the use of stem cells in combination with graft material. However, the survival of transplanted stem cells remains a major concern. The...
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Comparison of tooth movement and biological response in corticotomy and micro-osteoperforation in rabbits

Kim J, Kook YA, Bayome M, Park JH, Lee W, Choi H, Abbas NH

OBJECTIVE: The aim of this study was to evaluate the amount of tooth movement and histologic changes with different corticotomy designs and micro-osteoperforation in rabbits. METHODS: The sample consisted of 24...
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Human spermatozoa anti-proprotein convertase subtilisin/kexin type 4 synthesis using New Zealand rabbit for novel immunocontraception in males

Dahril , Aulanni'am , Keumala V, Mustafa A

PURPOSE: Proprotein convertase subtilisin/kexin type 4 (PCSK4, a 54-kDa protease) is expressed in the plasma membrane of the acrosome in human spermatozoa. It plays a critical role in penetrating the...
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Development of a Novel Intraoperative Neuromonitoring System Using a Surface Pressure Sensor to Detect Muscle Movement: A Rabbit Model Study

Sung ES, Lee JC, Shin SC, Kwon HG, Kim MS, Kim DJ, Ro JH, Lee BJ

OBJECTIVES: False-negative or false-positive responses in intraoperative neuromonitoring (IONM) using electromyography (EMG) in thyroid surgery pose a challenge. Therefore, we developed a novel IONM system that uses a surface pressure...
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Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graft Restenosis

Li Y, Wang L, Chen S, Yu D, Sun W, Xin S

PURPOSE: To explore the effects of biodegradable magnesium alloy stents (BMAS) on remodeling of vein graft (VG) anastomotic restenosis. MATERIALS AND METHODS: To establish a VG restenosis model, seventy two New...
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Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging

Wang Y, Zhang X, Wang B, Xie Y, Wang Y, Jiang X, Wang R, Ren K

OBJECTIVE: To examine the potential of intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) magnetic resonance imaging for detecting renal changes after iodinated contrast-induced acute kidney injury (CI-AKI) development...
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Are critical size bone notch defects possible in the rabbit mandible?

Carlisle P, Guda T, Silliman D, Hale RG, Brown Baer PR

OBJECTIVES: Small animal maxillofacial models, such as non-segmental critical size defects (CSDs) in the rabbit mandible, need to be standardized for use as preclinical models of bone regeneration to mimic...
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Improvement of the osteogenic potential of ErhBMP-2-/EGCG-coated biphasic calcium phosphate bone substitute: in vitro and in vivo activity

Hwang JH, Oh S, Kim S

PURPOSE: The aim of this study was to evaluate the enhancement of osteogenic potential of biphasic calcium phosphate (BCP) bone substitute coated with Escherichia coli-derived recombinant human bone morphogenetic protein-2...
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Mesenchymal Stem Cells Decrease Tunnel Widening of Anterior Cruciate Ligament Reconstruction in Rabbit Model

Hur CI, Ahn HW, Seon JK, Song EK, Kim GE

BACKGROUND AND OBJECTIVES: The study investigated the effect of mesenchymal stem cells (MSCs) or fibrin glue on tunnel widening after anterior cruciate ligament (ACL) reconstruction compared with biologic free control...
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Intra-articular Recombinant Human Growth Hormone Injection Compared with Hyaluronic Acid and Placebo for an Osteoarthritis Model of New Zealand Rabbits

Lubis AM, Wonggokusuma E, Marsetio A

PURPOSE: Up to now, there is no feasible solution for stopping or reversing the degenerative process of osteoarthritis (OA). Our study evaluated the effect of intra-articular injection of growth hormone...
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A Comparative Study of the Effects of Different Decellularization Methods and Genipin-Cross-Linking on the Properties of Tracheal Matrices

Zhong Y, Jiang A, Sun F, Xiao Y, Gu Y, Wu L, Zhang Y, Shi H

BACKGROUND: Different decellularization methods can affect the integrity and the biomechanical and biocompatible properties of the tracheal matrix. Natural cross-linking with genipin can be applied to improve those properties. The...
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Development of a Post-vitrectomy Injection of N-methyl-N-nitrosourea as a Localized Retinal Degeneration Rabbit Model

Ahn SM, Ahn J, Cha S, Yun C, Park TK, Goo YS, Kim SW

Since genetic models for retinal degeneration (RD) in animals larger than rodents have not been firmly established to date, we sought in the present study to develop a new rabbit...
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Decellularization of Trachea With Combined Techniques for Tissue-Engineered Trachea Transplantation

Batioglu-Karaaltin A, Ovali E, Karaaltin , Yener M, Yılmaz M, Eyüpoğlu F, Yılmaz YZ, Bozkurt ER, Demir N, Konuk E, Bozdağ ES, Yiğit O, Cansiz H

OBJECTIVES: The purpose of this study is to shorten the decellularization time of trachea by using combination of physical, chemical, and enzymatic techniques. METHODS: Approximately 3.5-cm-long tracheal segments from 42 New...
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Bone and tissue reaction of porous nickel-titanium alloy implant for dental implants in rabbits

Min GH, Lee KH, Sung SJ, Lee WP, Yu SJ, Kim BO

Porous nickel–titanium (Ni-Ti) alloy implants have been previously introduced, and many studies have been performed. Porous Ni-Ti alloys have excellent properties for use in the dental field. Thus, the use...
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Capsaicin-Induced Apoptosis in MBT-2 Murine Bladder Tumor Cells and Bladder Wall Penetration Effect of the Nano-Encapsulated Capsaicin in Rabbit

Cho SJ, Moon HW, Bae WJ, Park YH, Ha US, Hong SH, Kim SW, Lee JY

PURPOSE: In this study, we attempted to characterize capsaicin's effects with regard to the apoptosis of murine bladder cancer cells (MBT-2) as well as the pharmacodynamics of nano-encapsulated capsaicin formulation...
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Study of the cartilage matrix production-promoting effect of chicken leg extract and identification of the active ingredient

Yamada H, Nakamura U, Nakamura T, Uchida Y, Yamatsu A, Kim M

BACKGROUND/OBJECTIVES: Osteoarthritis (OA) is a major public health issue in Japan and other countries, and foods that prevent or treat OA are in strong demand. Proteins and peptides in chicken...
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The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits

Nakornnoi , Leethanakul C, Samruajbenjakun B

OBJECTIVE: To determine the effects of a local injection of leukocyte-platelet-rich plasma (L-PRP) on orthodontic tooth movement in rabbits. METHODS: Twenty-three male New Zealand white rabbits were included in a split-mouth...
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Production of polyclonal antibody against kidney antigens: a model for studying autoantibody in feline chronic kidney diseases

Songaksorn N, Petsophonsakul W, Pringproa , Lampang KN, Sthitmatee N, Sriphawattana N, Thongkorn

Chronic kidney disease is considered to be most common in geriatric domestic cats. It has been reported that the feline viral rhinotracheitis, calicivirus, and panleukopenia (FVRCP) vaccine prepared from the...
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