J Korean Ophthalmol Soc.  1986 Dec;27(6):1037-1043.

Comparison of Blood-Ocular-Barrier between White Rabbits and Colored Rabbits

• Park CS
• Kwak HW

Abstract

The purpose of this paper is to investigate the extent of destruction Blood-ocularbarrier between colored rabbits and white rabbits after photocoagulation, as preliminary experiment for the using colored and white rabbits. A total of 10 rabbits (5 white rabbits, 5 colored rabbits) were used. Photocoagulation in the right eye of 5 white rabbits and 5 colored rabbits were performed. The left eye of all the rabbits was control eye and the right eye was laser treated eye. After 3 days, a dose of 25mg/kg of 10% fluorescein sodium was injected in the ear vein of rabbit intravenously. We sampled aquous humor in anterior chamber and vitreous, and checked fluorescein concentration in anterior chamber and vitreous using HPLC (High Performance Liquid Chromatography). The results obtained were as follows; In experimental animals, 1. There is no significance between colored rabbits and white rabbits in fluorescein concentration of vitreous and aquous humor in control group. 2. The concentration of the fluorescein in the anterior chamber and vitreous of the right photocoagulated eye was higher than control eye, but there is no significance between colored rabbits and white rabbits. 3. there is no significance between colored rabbits and white rabbits in extent of destruction of Blood-ocular-barrier after Laser photocoagulation.

MeSH Terms

Animals
Anterior Chamber
Chromatography, High Pressure Liquid
Ear
Fluorescein
Light Coagulation
Rabbits*
Veins
Fluorescein