J Korean Ophthalmol Soc.  1999 Feb;40(2):587-595.

Effects of Intraoperative Exposure and Postoperative Subconjunctival Injections of 5-fluorouracil in Reducing Adhesions after Strabismus Surgery in Rabbits

• Whang CH
• Chang SI
• Moon NJ

Abstract

Recently, antimetabolotes such as 5-fluorouracil and mitomycin have been used successfully to reduce postoperative adhesions in animal models after strabismus surgery.Nine rabbits, 18 eyes, 36 areas were divided into 4 groups. The first group was a control one. The second group was treated with 5-fluorouracil intraoperatively. The third group was treated in the same manner as the second group, followed by subconjunctival injections of 5-fluorouracil from postoperative 7th day. The fourth group was treated with mitomycin C intraoperatively.The thied group(booster group) and the fourth group(mitomycin group) were superior to the others in preventing the postoperative adhesions. There was no statistically significant diference in scar length and adhesion grade between booster group and mitomycin group.This study reveals that the subconjunctival injections of 5-fluorouracil after intraoperative contact may reduce postoperative adhesions in secondary strabismus surgery and may prevent the possible serious complications of mitomycin C, giving the similar effect to potent mitomycin C.

Keyword

5-Fluorouracil; Postoperative adhesions; Strabismus surgery

MeSH Terms

Cicatrix
Fluorouracil*
Mitomycin
Models, Animal
Rabbits*
Strabismus*
Fluorouracil
Mitomycin