J Korean Ophthalmol Soc.  1998 Mar;39(3):591-597.

The Effect of Mitomycin C and Daunorubicin on the Healing Process in Rabbit Extraocular Muscle Surgery

• Oh SY
• Chang BL

Abstract

One of the most serious complications following strabismus surgery is the formation of adhesions that may result in restrictive ocular motility dysfunction. Management of the postoperative adhesions is often difficult. We investigated the effect of mitomycin c(MMC) and daunorubicin(DR) on postoperative would healing in rabbit extraocular muscle surgery after single intraoperative application. Sixteen white rabbits(32 eyes), weighing 2.0~2.5kg were used. These rabbits were divided into 4 groups; control group(BSS for 5 minutes exposure), group 1 (0.5mg/ml MMC for 1 minute exposure), group 2 (0.5mg/ml MMC for 5 minutes exposure), and group 3(25microgram/ml DR for 5 minutesexposure). Histopathologically, there was a more significant reduction of fibroblast and collagen fiber proliferation in group 1 and 2 than the control group. In group 3, these effects were better than the control group, but less than group 1 or 2. Immunohistochemically, group 1 and 2 showed greater effects of fibroblast growth factor (FGF) than the control group. In group 3, less effect was shown than group 1 or 2, but no difference was noted compare with the control group. These results suggest that intraoperative application of mitomycin c in strabismus surgery can increase a surgical success rate. However, daunorubicin is still controversial and more studies are needed on the dose and exposure time.

Keyword

Daunorubicin; Fibroblast growth factor; Mitomycin c; Strabis-mus surgery

MeSH Terms

Collagen
Daunorubicin*
Fibroblast Growth Factors
Fibroblasts
Mitomycin*
Rabbits
Strabismus
Collagen
Daunorubicin
Fibroblast Growth Factors
Mitomycin